Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer.
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DOI: 10.1016/j.bioorg.2021.105026
Abstract: In this work, two series of cyclic amine-containing benzimidazole carboxamide derivatives were designed and synthesized as potent anticancer agents. PARP1/2 inhibitory activity assays indicated that most of the compounds showed significant activity. The in vitro… read more here.
Keywords: piperidin benzo; imidazole carboxamide; carboxamide; benzo imidazole ... See more keywords