Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.024
Abstract: Therapies addressing multiple stages of Plasmodium falciparum life cycle are highly desirable for implementing malaria elimination strategies. MMV019918 (1, 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine) was selected from the MMV Malaria Box for its dual activity against both asexual stages… read more here.
Keywords: bromo chlorophenyl; methyl methanamine; piperidin methyl; chlorophenyl furan ... See more keywords
Synthesis of polysubstituted phenyl acetates via FeCl3-mediated domino reaction of 2-(aryl(piperidin-1-yl)methyl)phenols and 1,3-diketones
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DOI: 10.1016/j.tet.2017.10.045
Abstract: Abstract A one-pot domino reaction involving Lewis acid-mediated nucleophilic-substitution/intramolecular-cyclization/reverse Claisen condensation of 2-(aryl(piperidin-1-yl)methyl)phenols and 1,3-diketones has been developed for the synthesis of 2-(3-oxo-1-phenylbutyl)phenyl acetates in good to excellent yields (77%–95%). The construction of the products… read more here.
Keywords: methyl phenols; domino reaction; domino; aryl piperidin ... See more keywords
Impact of Thiocyanate on Catalytic Abilities of Metal Complexes of 4-N-(4-hydroxy-3-((piperidin-1-yl)methyl) phenyl)acetamide (HL). X-ray Crystal Structure of HL
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DOI: 10.37358/rc.20.9.8324
Abstract: Four new [copper(II) and iron(III)] complexes were synthesized using N-(4-hydroxy-3((piperidin-1-yl)methyl)phenyl)acetamide (HL) a Mannich base as ligand. All compounds were successfully characterized by elemental analysis, conductivity measurements, Ultraviolet-visible, Infrared, and Nuclear Magnetic Resonance spectroscopy. Furthermore, the… read more here.
Keywords: piperidin methyl; metal complexes; methyl phenyl; phenyl acetamide ... See more keywords