Synthesis, Crystal Structure, DFT Calculations and Hirshfeld Surface Analysis of 3-Chloro-3-methyl-r(2),c(6)-bis(p-methoxyphenyl)piperidin-4-one
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Crystallography"
DOI: 10.1007/s10870-018-0759-6
Abstract: The title compound, C20H22ClNO3, [common name: 3-chloro-3-methyl-r(2),c(6)-bis(p-methoxyphenyl)piperidin-4-one] crystallizes in the P21/c space group with unit cell parameters a = 13.4020(11) Å, b = 7.7888(5) Å and c = 18.1721(14) Å, β = 108.250(9)°, Z = 4. The central piperidin-4-one ring (N1/C1–C5), adopts a slightly distorted… read more here.
Keywords: crystal structure; hirshfeld surface; surface; geometry ... See more keywords
Design, synthesis and biological evaluation of 7-(5-((substituted - amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues as anticancer agents.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104865
Abstract: A series of thirty-one novel 7-(5-((amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues (Cst 1 - 31) have been designed, synthesized and characterized by 1H NMR, 13C NMR and MS spectral analysis. Here, we evaluated the anticancer potential and biological… read more here.
Keywords: spiro chroman; piperidin one; thiophen spiro; chroman piperidin ... See more keywords
Ca2+ ion sensing by a piperidin-4-one derivative and the effect of β-cyclodextrin complexation on the sensing
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2017.01.021
Abstract: Abstract In this paper, we report the turn-on fluorescence based Ca 2+ ion sensing by an anthracene piperidin-4-one derivative. The compound is obtained using a simple two step synthesis. The compound is characterized using NMR… read more here.
Keywords: cyclodextrin; ion sensing; one derivative; compound ... See more keywords