Recent advancement of piperidine moiety in treatment of cancer- A review.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.017
Abstract: Piperidine is an important pharmacophore, a privileged scaffold and an excellent heterocyclic system in the field of drug discovery which provides numerous opportunities in studying/exploring this moiety as an anticancer agent by acting on various… read more here.
Keywords: cancer review; piperidine; moiety; treatment cancer ... See more keywords
Piperidine alkaloids and xanthone from the roots of Caulophyllum robustum Maxim.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2018.07.014
Abstract: Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined… read more here.
Keywords: piperidine; caulophyllum robustum; roots caulophyllum; robustum maxim ... See more keywords
Design, synthesis and structure of novel dendritic G-2 melamines comprising piperidine motifs as key linkers and 4-(n-octyloxy)aniline as a peripheral unit
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.130468
Abstract: Abstract Starting from 4-amino-1-(tert-butoxycarbonyl)piperidine (Boc-PD-NH2), we report the synthesis of three novel meta-tri- and dimeric tetravalent N-substituted melamines with piperidin-4-yl groups. These compounds were used as central building-blocks and successfully incorporated into three new G-2… read more here.
Keywords: peripheral unit; octyloxy aniline; design synthesis; aniline peripheral ... See more keywords
Thermal imidization behaviors of 6FDA-ODA poly(amic acid) containing curing accelerators by in-situ FTIR spectroscopy
Sign Up to like & getrecommendations! Published in 2020 at "Vibrational Spectroscopy"
DOI: 10.1016/j.vibspec.2019.103007
Abstract: Abstract In-situ FTIR spectroscopic measurements were used to examine the thermal imidization behaviors of 6FDA-ODA PAA films in the presence of a strong tertiary amine base, such as piperazine, N,N’-dimethyl piperazine, piperidine, and 2,6-dimethyl piperidine.… read more here.
Keywords: curing accelerators; piperidine; dimethyl; imidization ... See more keywords
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01964
Abstract: High affinity phenyl-piperidine P2Y14R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopentylamino derivatives preserved human P2Y14R affinity (fluorescence binding assay),… read more here.
Keywords: piperidine; high affinity; affinity; bridged piperidine ... See more keywords
Switching Electrophile Intermediates to Nucleophiles: Michael and Oxa-Diels-Alder Reactions to Afford Polyoxy-Functionalized Piperidine Derivatives with Tetrasubstituted Carbon.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00735
Abstract: Michael, Michael-annulation, and oxa-Diels-Alder reactions of carbohydrate derivatives that afford polyoxy-functionalized piperidine derivatives bearing tetrasubstituted carbon at the 3-position of the piperidine ring are reported. Iminium ions generated from carbohydrate derivatives with amines were converted… read more here.
Keywords: diels alder; piperidine; afford polyoxy; oxa diels ... See more keywords
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
Sign Up to like & getrecommendations! Published in 2021 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.1c00435
Abstract: In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported H3R ligands… read more here.
Keywords: affinity; sigma; piperidine; receptor antagonists ... See more keywords
Renewable energy storage via efficient reversible hydrogenation of piperidine captured CO2
Sign Up to like & getrecommendations! Published in 2018 at "Green Chemistry"
DOI: 10.1039/c8gc00954f
Abstract: The storage of renewable energy is the major hurdle during the transition of fossil resources to renewables. A possible solution is to convert renewable electricity to chemical energy carriers such as hydrogen for storage. Herein,… read more here.
Keywords: storage; hydrogen storage; energy; piperidine ... See more keywords
Covalent cross-linked anion exchange membrane based on poly(biphenyl piperidine) and poly(styrene-b-(ethylene-co-butylene)-b-styrene): preparation and properties
Sign Up to like & getrecommendations! Published in 2021 at "Polymer-Plastics Technology and Materials"
DOI: 10.1080/25740881.2021.1888987
Abstract: ABSTRACT Poly(biphenyl piperidine) and polystyrene‑b‑poly(ethylene-co-butylene)‑b‑polystyrene were cross-linked to form a polymer backbone, piperidine as the ionic conducting group to improve the chemical stability of the anion exchange membrane. Results indicate that the cross-linked membranes could… read more here.
Keywords: poly biphenyl; piperidine; cross linked; styrene ... See more keywords
Crystal structure of 4-methoxy-N-(piperidine-1-carbonothioyl)benzamide
Sign Up to like & getrecommendations! Published in 2017 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017013317
Abstract: In the title benzoylthiourea derivative (MPiCB), the piperidine ring has a chair conformation and its mean plane is inclined to the 4-methoxybenzene ring by 63.0 (3)°. read more here.
Keywords: crystal structure; piperidine; methoxy piperidine; carbonothioyl benzamide ... See more keywords
1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology"
DOI: 10.1159/000513376
Abstract: Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be… read more here.
Keywords: binge eating; piperidine; boc piperidine; eating behaviour ... See more keywords