Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1783664
Abstract: Abstract Tubulin polymerisation inhibitors that target colchicine binding site were powerful anticancer agents. Although along the years many colchicine binding site inhibitors (CBSIs) have been reported, few piperidine derivatives were identified as CBSIs. In this… read more here.
Keywords: pc3 cells; binding site; piperidine derivatives; colchicine binding ... See more keywords
Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach
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DOI: 10.3390/ijms23179927
Abstract: Aedes aegypti mosquitoes transmit several human pathogens that cause millions of deaths worldwide, mainly in Latin America. The indiscriminate use of insecticides has resulted in the development of species resistance to some such compounds. Piperidine,… read more here.
Keywords: aedes aegypti; potential new; new aedes; piperidine derivatives ... See more keywords
Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications
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DOI: 10.3390/ijms24032937
Abstract: Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids.… read more here.
Keywords: synthesis pharmacological; pharmacological applications; piperidine derivatives; advances synthesis ... See more keywords
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
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DOI: 10.3390/molecules25020299
Abstract: In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting… read more here.
Keywords: synthesis antimalarial; piperidine derivatives; antimalarial activity; disubstituted piperidine ... See more keywords