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Published in 2018 at "Current computer-aided drug design"
DOI: 10.2174/1573409914666180726092800
Abstract: INTRODUCTION Acetylcholinesterase enzyme (AChE) is the main target in Alzheimer's disease therapy and designing of novel AChE inhibitors is a great deal of attention. METHODS In this study, 2D-QSAR and 3D-QSAR models were generated using…
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Keywords:
study novel;
piperazine derivatives;
novel piperidine;
piperidine piperazine ... See more keywords
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Published in 2017 at "Informs Journal on Computing"
DOI: 10.4236/ijoc.2017.74029
Abstract: A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine, thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione were synthesized from cheap, available and biologically active stearic acid. 2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which…
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Keywords:
piperazine;
fatty acids;
non ionic;
piperidine piperazine ... See more keywords