Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers.
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DOI: 10.1021/acs.orglett.2c04067
Abstract: We report the synthesis of piperidino nucleoside phosphoramidates functionalized with uracil, cytosine, guanine, and adenine and their incorporation into oligomers. High-performance liquid chromatography analyses demonstrated that a phosphorodiamidate piperidino oligomer (PPO) is more lipophilic than… read more here.
Keywords: biophysical properties; piperidino oligomers; phosphorodiamidate piperidino; piperidino ... See more keywords