Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Oncology"
DOI: 10.1007/s13402-018-0397-1
Abstract: PurposePreviously, compounds containing a piperidone structure have been shown to be highly cytotoxic to cancer cells. Recently, we found that the piperidone compound P2 exhibits a potent anti-neoplastic activity against human breast cancer-derived cells. Here,… read more here.
Keywords: lymphoma cells; induction; leukemia lymphoma; piperidone ... See more keywords
Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers
Sign Up to like & getrecommendations! Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.07.004
Abstract: For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was… read more here.
Keywords: crown ethers; synthesis cytotoxicity; dibenzo diaza; piperidone ... See more keywords
Sadopeptins A and B, Sulfoxide- and Piperidone-Containing Cyclic Heptapeptides with Proteasome Inhibitory Activity from a Streptomyces sp.
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DOI: 10.1021/acs.jnatprod.2c00978
Abstract: New sulfur-bearing natural products, sadopeptins A and B (1 and 2), were discovered from Streptomyces sp. YNK18 based on a targeted search using the characteristic isotopic signature of sulfur in mass spectrometry analysis. Compounds 1… read more here.
Keywords: cyclic heptapeptides; spectroscopy; piperidone; inhibitory activity ... See more keywords
Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
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DOI: 10.1371/journal.pone.0227727
Abstract: We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome’s 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a michael acceptor that adducts Cysteine… read more here.
Keywords: cell lines; ra375; piperidone; function ... See more keywords