Piperine Decreases Binding of Drugs to Human Plasma and Increases Uptake by Brain Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5929
Abstract: We previously reported that piperine, an active alkaloidal principal of black and long peppers, enhances drug bioavailability by inhibiting drug metabolism. Another mechanism influencing drug availability/uptake is its free fraction. Since piperine is highly lipophilic,… read more here.
Keywords: human plasma; brain microvascular; drug; piperine ... See more keywords
Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10055-9
Abstract: Abstract Piperine is the main active component of Piper longum L., which is also the main component of anti-sciatica Mongolian medicine Naru Sanwei pill. It has many pharmacological activities such as anti-inflammatory and immune regulation.… read more here.
Keywords: piper longum; sciatica; pharmacology; piperine ... See more keywords
Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02497-5
Abstract: Inflammation, demyelination, glial activation, and oxidative damage are the most pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black pepper, possesses antioxidant, anti-inflammatory, and neuroprotective properties whose therapeutic potential has been… read more here.
Keywords: anti inflammatory; eae; piperine; autoimmune encephalomyelitis ... See more keywords
Pepper with and without a sting: Brain processing of intranasal trigeminal and olfactory stimuli from the same source
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.07.010
Abstract: Humans have distinct and overlapping brain regions for the processing of intranasal olfactory or trigeminal stimuli. It may be assumed that trigeminal stimulants and "trigeminal-free" odorous stimuli from the same source are processed differently in… read more here.
Keywords: stimuli source; pepper; piperine; peppereo ... See more keywords
The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173524
Abstract: Myocardial infarction (MI) eventually exacerbates inflammatory response due to the release of inflammatory and pro-inflammatory factors. The aim of this study is to explore the protective efficacy of piperine supplementation against the inflammatory response in… read more here.
Keywords: isoproterenol; iso; group; inflammation ... See more keywords
Application of film-forming solution as a transdermal delivery system of piperine-rich herbal mixture extract for anti-inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04139
Abstract: Piperine-rich herbal mixture (PHM) used in this study is a traditional Thai medicine that contains 21 oriental herbs. It is called “Sahastara remedy” and is officially included in the Thai National List of Essential Medicine… read more here.
Keywords: anti inflammatory; medicine; phm ffs; piperine ... See more keywords
Piperine ameliorated lupus nephritis by targeting AMPK‐mediated activation of NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.10.025
Abstract: Background: Lupus nephritis (LN) is a leading cause of mortality. The activation of NLRP3 inflammasome contributed to LN development and thus became a therapeutic target. Here we assessed the therapeutic potential of piperine, a bioactive… read more here.
Keywords: activation nlrp3; lupus nephritis; piperine; activation ... See more keywords
Time‐dependent inhibition of carbamazepine metabolism by piperine in anti‐epileptic treatment
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.060
Abstract: Aims: The first‐line anti‐epileptic agent carbamazepine has narrow therapeutic index and can potentially interact with piperine, the major component from black pepper. The present study aimed to delineate the mechanism of such interaction for safe… read more here.
Keywords: time dependent; piperine; carbamazepine; carbamazepine metabolism ... See more keywords
Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.10.006
Abstract: Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats… read more here.
Keywords: combination; ohda induced; piperine; piperine combination ... See more keywords
Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.04.008
Abstract: In recent years, piperine has attracted much attention due to its various biological effects as a neuroprotective agent. Therefore, clarification of the possible side effects of piperine is important to identify its potential pharmacological action.… read more here.
Keywords: high dose; long term; model; piperine ... See more keywords
Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2016.12.016
Abstract: The phytochemical profile of Macropiper excelsum (G.Forst.) Miq. subsp. excelsum (Piperaceae), a shrub which is widespread in New Zealand, was investigated by LC-MS-guided isolation and characterization via HR-ESI-TOF-MS and NMR spectroscopy. The isolated compounds were… read more here.
Keywords: uptake; caco cells; piperine; macropiper excelsum ... See more keywords