Evaluation of the antiparasitic and antifungal activities of new synthetic piperlongumine-type cinnamide derivatives: booster effect by halogen substituents.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300132
Abstract: A series of synthetic N-acylpyrrolidone and -piperidone derivatives of the natural alkaloid piperlongumine were prepared and tested for their activities against Leishmania major and Toxoplasma gondii parasites. Replacement of one of the aryl meta-methoxy groups… read more here.
Keywords: piperlongumine; antifungal activities; activities new; antiparasitic antifungal ... See more keywords
Decrypting the interaction pattern of Piperlongumine with calf thymus DNA and dodecamer d(CGCGAATTCGCG)2 B-DNA: Biophysical and molecular docking analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106808
Abstract: The mechanisms of interaction of DNA with pharmacological molecules are critical to understanding their therapeutic actions on physiological systems. Piperlongumine is widely studied for its anticancer potential. Multi-spectrometry, calorimetry and in silico studies were employed… read more here.
Keywords: dna; piperlongumine; calf thymus; interaction ... See more keywords
Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.057
Abstract: Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L. (long piper), a medical plant known from Ayurvedic medicine. Although was discovered well over fifty years ago, its pharmacological properties have been… read more here.
Keywords: piplartine lead; piperlongumine piplartine; piperlongumine; anticancer ... See more keywords
Keto‐enol‐based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.03.029
Abstract: ABSTRACT Altered redox status including higher levels of copper in cancer cells than in normal cells inspired many researchers to develop copper ionophores targeting this status. We have recently found that flavon‐3‐ol (3‐HF) works as… read more here.
Keywords: keto enol; piperlongumine; hepg2 cells; death ... See more keywords
Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1445769
Abstract: ABSTRACT Malignant melanoma is a devastating skin cancer due to its severe drug resistance and prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural product with defined structure. While numerous studies revealed exceptional inhibitory effects… read more here.
Keywords: melanoma; reactive oxygen; oxygen species; melanoma cells ... See more keywords
Abstract 3518: Piperlongumine, a novel treatment option to overcome BRAF inhibitor resistance in melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3518
Abstract: Tumor cell metabolism is a hallmark of chemoresistance and its role has been well-defined in BRAF inhibitor resistance in melanoma. Melanoma cells are highly proliferative and are shown to develop addiction towards the metabolic pathways… read more here.
Keywords: melanoma; treatment; piperlongumine; braf inhibitor ... See more keywords
Piperlongumine as anticancer agent: The story so far about killing many birds with one stone.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2018.64.11.19
Abstract: Piperlongumine is a biologically and pharmacologically active constituent of the plant Piper longum. This compound is gradually gaining attention because of its ability to inhibit/prevent different cancers. Modern era of molecular oncology is incomplete without… read more here.
Keywords: agent story; story far; anticancer agent; piperlongumine anticancer ... See more keywords
Identification of Piperlongumine as Potent Inhibitor of Necroptosis
Sign Up to like & getrecommendations! Published in 2023 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s397971
Abstract: Purpose Excessive necroptosis contributes to the pathogenesis of several inflammatory and neurodegenerative diseases. Here, using a high-throughput screening approach, we investigated the anti-necroptosis effects of piperlongumine, an alkaloid isolated from the long pepper plant, in… read more here.
Keywords: necroptosis; piperlongumine; tnf induced; inhibitor ... See more keywords