Perioperative pirfenidone treatment for lung cancer patients with idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Surgery Today"
DOI: 10.1007/s00595-019-01923-5
Abstract: Purpose To assess the efficacy and feasibility of perioperative pirfenidone treatment (PPT) in lung cancer patients with idiopathic pulmonary fibrosis (IPF). Methods The subjects of this retrospective review were 100 patients diagnosed with IPF, who… read more here.
Keywords: pirfenidone; treatment; ppt; lung cancer ... See more keywords
The curse of idiopathic
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inherited Metabolic Disease"
DOI: 10.1007/s10545-017-0101-z
Abstract: The anti-fibrotic drug pirfenidone has proven efficacy in slowing lung function decline in idiopathic pulmonary fibrosis (IPF). The registration studies were designed to include patients with IPF and to exclude patients with pulmonary fibrosis associated… read more here.
Keywords: fibrosis; disease; hps; pulmonary fibrosis ... See more keywords
Survival of patients with idiopathic pulmonary fibrosis and pulmonary hypertension under therapy with nintedanib or pirfenidone
Sign Up to like & getrecommendations! Published in 2021 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-021-02883-w
Abstract: Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause that leads to respiratory failure and death within few years of diagnosis. Pulmonary hypertension (PH) is a common… read more here.
Keywords: index; idiopathic pulmonary; dlco; gap index ... See more keywords
A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Therapy"
DOI: 10.1007/s12325-017-0594-8
Abstract: AbstractIntroduction Pirfenidone film-coated tablets were developed to offer an alternative to the marketed capsule formulation. This study assessed the bioequivalence of the tablet and capsule formulations under fed and fasted states.MethodsA Phase I, open-label, randomized,… read more here.
Keywords: bioequivalence; state; auc0; capsule ... See more keywords
Real-World Study Analysing Progression and Survival of Patients with Idiopathic Pulmonary Fibrosis with Preserved Lung Function on Antifibrotic Treatment
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DOI: 10.1007/s12325-020-01523-7
Abstract: Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible lung disease. Licensed treatment options for IPF are pirfenidone and nintedanib. The aim of this study was to assess the impact of antifibrotic therapy… read more here.
Keywords: lung function; treatment; study; pirfenidone ... See more keywords
Controlled delivery of pirfenidone through vitamin E-loaded contact lens ameliorates corneal inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0541-5
Abstract: Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye… read more here.
Keywords: vitamin loaded; delivery; drug; contact ... See more keywords
Pirfenidone attenuates the profibrotic contractile phenotype of differentiated human dermal myofibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.177
Abstract: Dysregulated wound healing after burn injury frequently results in debilitating hypertrophic scarring and contractures. Myofibroblasts, the main effector cells for dermal fibrosis, develop from normal fibroblasts via transforming growth factor beta 1 (TGF-β1). During wound… read more here.
Keywords: contractile; pirfenidone attenuates; profibrotic contractile; contractile phenotype ... See more keywords
In vitro and in vivo evaluation of pirfenidone loaded acrylamide grafted pullulan-poly(vinyl alcohol) interpenetrating polymer networks.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.08.135
Abstract: The aim of present study was to develop controlled release formulation of pirfenidone using acrylamide grafted pullulan. Interpenetrating polymer network (IPN) microspheres were prepared using acrylamide grafted pullulan and PVA utilizing glutaraldehyde assisted water-in-oil emulsion… read more here.
Keywords: grafted pullulan; pirfenidone; interpenetrating polymer; acrylamide grafted ... See more keywords
Clinical Molecular Imaging of Pulmonary CXCR4 Expression to Predict Outcome of Pirfenidone Treatment in IPF.
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DOI: 10.1016/j.chest.2020.08.2043
Abstract: BACKGROUND IPF is a progressive disease for which two antifibrotic drugs have recently been approved, however there is an unmet need to predict responses to antifibrotic treatment, such as pirfenidone. Recent data suggested that up-regulated… read more here.
Keywords: pulmonary cxcr4; cxcr4 expression; treatment; pirfenidone ... See more keywords
A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1 / JNK1 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108289
Abstract: Colon diseases are a major health burden, particularly ulcerative colitis, in both men and women worldwide. Environmental and genetic factors in various colonic pathologies influence the onset and outcome of diseases. As the evidence from… read more here.
Keywords: jnk1; tgf; ulcerative colitis; acetic acid ... See more keywords
Pirfenidone alleviates lipopolysaccharide-induced lung injury by accentuating BAP31 regulation of ER stress and mitochondrial injury.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102464
Abstract: Pirfenidone has been widely used in the treatment of idiopathic pulmonary fibrosis (IPF). However, the role of pirfenidone in LPS-induced acute lung injury (ALI) remains unclear. This study aims to investigate the protective effects of… read more here.
Keywords: mitochondrial injury; stress mitochondrial; injury; pirfenidone ... See more keywords