Pirfenidone attenuates the profibrotic contractile phenotype of differentiated human dermal myofibroblasts.
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DOI: 10.1016/j.bbrc.2019.10.177
Abstract: Dysregulated wound healing after burn injury frequently results in debilitating hypertrophic scarring and contractures. Myofibroblasts, the main effector cells for dermal fibrosis, develop from normal fibroblasts via transforming growth factor beta 1 (TGF-β1). During wound… read more here.
Keywords: contractile; pirfenidone attenuates; profibrotic contractile; contractile phenotype ... See more keywords