Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
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DOI: 10.1158/1538-7445.am2017-lb-304
Abstract: Heat shock factor 1 (HSF1) was originally identified as a master regulator of the classical ‘cytoprotective’ heat shock response. However, a large body of evidence has now verified the importance of HSF1 to tumorigenesis and… read more here.
Keywords: phenotypic screen; probe; hsf1; pirin ... See more keywords
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors
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DOI: 10.3390/antiox11020262
Abstract: The evolutionary conserved non-heme Fe-containing protein pirin has been implicated as an important factor in cell proliferation, migration, invasion, and tumour progression of melanoma, breast, lung, cervical, prostate, and oral cancers. Here we found that… read more here.
Keywords: human colorectal; pirin; pirin nrf2; overexpressed human ... See more keywords