To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society transactions"
DOI: 10.1042/bst20201171
Abstract: Piwi-interacting RNAs (piRNAs) defend animal gonads by guiding PIWI-clade Argonaute proteins to silence transposons. The nuclear Piwi/piRNA complexes confer transcriptional repression of transposons, which is accompanied with heterochromatin formation at target loci. On the other… read more here.
Keywords: export factor; nuclear export; export; export export ... See more keywords
Biological significance of piRNA in liver cancer: a review
Sign Up to like & getrecommendations! Published in 2020 at "Biomarkers"
DOI: 10.1080/1354750x.2020.1794041
Abstract: Abstract Liver cancer is one of the most common and deadly cancers in the world. In recent years, non-coding RNA has been a hot topic in liver cancer research. piRNAs (PIWI-interacting RNAs) are a new… read more here.
Keywords: liver; pirna; liver cancer; cancer review ... See more keywords
Yb body assembly on the flamenco piRNA precursor transcripts reduces genic piRNA production
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-10-0591
Abstract: In Drosophila ovarian somatic cells, PIWI-interacting small RNAs (piRNAs) against transposable elements are mainly produced from the ∼180-kb flamenco (flam) locus. flam transcripts are gathered into foci, located close to the nuclear envelope, and processed… read more here.
Keywords: body; body assembly; pirna production; pirna ... See more keywords
piRNA Clusters Need a Minimum Size to Control Transposable Element Invasions
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa064
Abstract: Abstract piRNA clusters are thought to repress transposable element (TE) activity in mammals and invertebrates. Here, we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: The total… read more here.
Keywords: minimum size; pirna; transposable element; pirna clusters ... See more keywords
Contrasting Sex-and Caste-Dependent piRNA Profiles in the Transposon Depleted Haplodiploid Honeybee Apis mellifera
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evx087
Abstract: Abstract Protecting genome integrity against transposable elements is achieved by intricate molecular mechanisms involving PIWI proteins, their associated small RNAs (piRNAs), and epigenetic modifiers such as DNA methylation. Eusocial bees, in particular the Western honeybee,… read more here.
Keywords: transposon depleted; pirna; honeybee apis; apis mellifera ... See more keywords
Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac541
Abstract: Abstract The histone variant H3.3 is encoded by two distinct genes, H3f3a and H3f3b, exhibiting identical amino-acid sequence. H3.3 is required for spermatogenesis, but the molecular mechanism of its spermatogenic function remains obscure. Here, we… read more here.
Keywords: spermatogenesis; role; pirna; regulation ... See more keywords
The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1266
Abstract: Abstract PIWI-interacting RNAs (piRNAs) comprise a class of small RNAs best known for suppressing transposable elements in germline tissues. The vector mosquito Aedes aegypti encodes seven PIWI genes, four of which are somatically expressed. This… read more here.
Keywords: pong amplification; pirna; tudor; veneno assembles ... See more keywords
Prediction of Piwi-Interacting RNAs and Their Functions via Convolutional Neural Network
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Access"
DOI: 10.1109/access.2021.3070083
Abstract: In eukaryotic cells, Piwi-interacting RNAs (piRNAs) are the type of short chain non-coding RNA molecules, which interconnect with PIWI proteins. It performs various cellular and genetic functions such as gene-specific protein translation, expression regulation, maintenance,… read more here.
Keywords: neural network; piwi interacting; interacting rnas; convolutional neural ... See more keywords
Novel piRNA Regulates PIWIL1 to Modulate the Behavior of Placental Trophoblast Cells and Participates in Preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7856290
Abstract: Objectives This study is aimed at investigating the role of PIWIL1/piRNA in the development of preeclampsia. Methods High-throughput sequencing was performed in 5 preeclampsia and 5 normal placentas to get a piRNA expression profile. WGCNA… read more here.
Keywords: piwil1; expression; preeclampsia; trophoblast cells ... See more keywords
WIND (Workflow for pIRNAs aNd beyonD): a strategy for in-depth analysis of small RNA-seq data
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.27868.3
Abstract: Current bioinformatics workflows for PIWI-interacting RNA (piRNA) analysis focus primarily on germline-derived piRNAs and piRNA-clusters. Frequently, they suffer from outdated piRNA databases, questionable quantification methods, and lack of reproducibility. Often, pipelines specific to miRNA analysis… read more here.
Keywords: small rna; analysis; analysis small; pirna ... See more keywords
Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008861
Abstract: In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). Expression of genomic TEs is proposed to… read more here.
Keywords: genomic auto; cytoplasmic pirna; pirna pathway; auto immunity ... See more keywords