Transcriptome-wide analyses of piRNA binding sites suggest distinct mechanisms regulate piRNA binding and silencing in C. elegans.
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DOI: 10.1261/rna.079441.122
Abstract: PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposon mRNAs and some endogenous mRNAs in various animals. However, C. elegans piRNAs only trigger gene silencing at select predicted targeting sites, suggesting additional cellular mechanisms regulate… read more here.
Keywords: regulate pirna; transcriptome wide; mechanisms regulate; distinct mechanisms ... See more keywords
Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
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DOI: 10.3390/genes13050800
Abstract: The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible… read more here.
Keywords: trinucleotide repeats; mirnas pirnas; interaction mirnas; pirna binding ... See more keywords