Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.07.011
Abstract: Summary PIWI proteins and their guiding Piwi-interacting small RNAs (piRNAs) are crucial for fertility and transposon defense in the animal germline. In most species, the majority of piRNAs are produced from distinct large genomic loci,… read more here.
Keywords: pirna clusters; evolutionarily labile; transposon; transposon regulation ... See more keywords
piRNA Clusters Need a Minimum Size to Control Transposable Element Invasions
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa064
Abstract: Abstract piRNA clusters are thought to repress transposable element (TE) activity in mammals and invertebrates. Here, we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: The total… read more here.
Keywords: minimum size; pirna; transposable element; pirna clusters ... See more keywords
The Expression Dynamics of piRNAs Derived From Male Germline piRNA Clusters and Retrotransposons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.868746
Abstract: In mammals, germ cells produce a class of small regulatory RNAs called PIWI-interacting RNAs or piRNAs, which are 25–32 nucleotides in length. The profile of testicular piRNAs changes during development. The piRNAs detected in fetal… read more here.
Keywords: type pirnas; expression dynamics; pirna clusters; germ cells ... See more keywords