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Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.107
Abstract: Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with PIWI subfamily proteins, which play an important role in transposon silencing in animal germ cell. The piRNAs biogenesis is divided into two…
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Keywords:
derived bmn4;
pirna pathway;
nuage;
ovary derived ... See more keywords
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Published in 2021 at "Nature Cell Biology"
DOI: 10.1038/s41556-021-00746-2
Abstract: PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are essential for male but not for female fertility. Here, we report…
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Keywords:
spermatogonia;
golden hamsters;
fertile oocytes;
pirna pathway ... See more keywords
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Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky761
Abstract: Abstract Transposable elements (TEs) are parasitic DNA sequences that threaten genome integrity by replicative transposition in host gonads. The Piwi-interacting RNAs (piRNAs) pathway is assumed to maintain Drosophila genome homeostasis by downregulating transcriptional and post-transcriptional…
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Keywords:
pathway controls;
controls germline;
pirna pathway;
transposition ... See more keywords
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Published in 2022 at "Insect Science"
DOI: 10.1111/1744-7917.13096
Abstract: As a defense mechanism against transposable elements, the PIWI‐interacting RNA (piRNA) pathway maintains genomic integrity and ensures proper gametogenesis in gonads. Numerous factors are orchestrated to ensure normal operation of the piRNA pathway. Spindle‐E (Spn‐E)…
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Keywords:
gametogenesis;
spindle essential;
mutant gonads;
bombyx mori ... See more keywords
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Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13160
Abstract: The Piwi-interacting RNA (piRNA) pathway has been shown to be involved in the antiviral defense against RNA viruses, especially in mosquitoes, but its universality has been questioned. Here, we used the Bombyx mori nucleopolyhedrovirus (BmNPV)-infected…
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Keywords:
piwi class;
replication;
lepidoptera;
pirna pathway ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1441
Abstract: Across Metazoa, Piwi proteins play a critical role in protecting the germline genome through piRNA-mediated repression of transposable elements. In vertebrates, activity of Piwi proteins and the piRNA pathway was thought to be gonad specific.…
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Keywords:
crest specification;
neural crest;
pirna pathway;
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Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008861
Abstract: In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). Expression of genomic TEs is proposed to…
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Keywords:
genomic auto;
cytoplasmic pirna;
pirna pathway;
auto immunity ... See more keywords
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Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.610665
Abstract: One of the main conditions of the species splitting from a common precursor lineage is the prevention of a gene flow between diverging populations. The study of Drosophila interspecific hybrids allows to reconstruct the speciation…
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Keywords:
ste;
melanogaster;
stellate genes;
pirna pathway ... See more keywords
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Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1129194
Abstract: piRNAs function as genome defense mechanisms against transposable elements insertions within germ line cells. Recent studies have unraveled that piRNA pathways are not limited to germ cells as initially reckoned, but are instead also found…
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Keywords:
defense mechanisms;
presence;
piwi;
evolution beyond ... See more keywords
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Published in 2023 at "Insects"
DOI: 10.3390/insects14020187
Abstract: Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs, exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most complex biogenesis and functional roles. Significant progress has…
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Keywords:
insects;
piwi proteins;
functional roles;
pirnas piwi ... See more keywords