P14.14.A 3D VOLUME GROWTH RATE OPENS NEW PERSPECTIVES FOR THE CLASSIFICATION OF AGGRESSIVE PITUITARY ADENOMAS
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.475
Abstract: WHO 2022 classification of neuroendocrine tumors states that there are currently no grading systems for pituitary adenomas (PitNET). Therefore, we aim to assess three-dimensional volume growth rate (3DVGR) in multiple PitNET and to correlate 3DVGR… read more here.
Keywords: pituitary adenomas; year; volume growth; growth rate ... See more keywords
Pituitary Neuroendocrine Tumor Organoids Generated from Induced Pluripotent Stem Cells Reveal the Dysregulation of Cell Lineage Differentiation in Cushing’s Disease
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DOI: 10.1152/physiol.2024.39.s1.2104
Abstract: Background: Cushing’s Disease (CD) is an endocrine disease typically caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET). Corticotroph subtype PitNETs subsequently stimulate the adrenal glands to overproduce causing a wide range of detrimental… read more here.
Keywords: disease; physiology; cell; cell lineage ... See more keywords
SAT-075 Revealing the Heterogeneity and Behavior of Pituitary Neuroendocrine Tumors in Cushing’s Disease Patients using Spatial Multiomics
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.2394
Abstract: Abstract J. Chakrabarti: None. N.E. Garrett: None. K. Hurth: None. J.D. Carmichael: None. M. Shiroishi: None. D. Weisenberger: None. E.R. Laws: None. C. Horbinski: None. A.B. Castro: None. J. Eschbacher: None. A.S. Little: None. Y.… read more here.
Keywords: disease; methylation; pituitary neuroendocrine; cushing disease ... See more keywords
Clinical and Pathological Features of Pit1/SF1 Multilineage Pituitary Neuroendocrine Tumor
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DOI: 10.1227/neu.0000000000002846
Abstract: BACKGROUND AND OBJECTIVES: Lineage-based classification has critical clinical implications in pituitary neuroendocrine tumor (PitNET). As the most prevalent subtype of multilineage PitNET, PitNET originating from both pituitary-specific positive transcription factor 1 (Pit1) and steroidogenic factor-1… read more here.
Keywords: sf1 adenoma; pitnet; pit1 sf1;
Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors
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DOI: 10.1371/journal.pone.0265306
Abstract: Somatic genetic alterations in pituitary neuroendocrine tumors (PitNET) tissues have been identified in several studies, but detection of overlapping somatic PitNET candidate genes is rare. We sequenced and by employing multiple data analysis methods studied… read more here.
Keywords: somatic variants; pitnet; neuroendocrine tumors; pituitary neuroendocrine ... See more keywords
SDF-1α/MicroRNA-134 Axis Regulates Nonfunctioning Pituitary Neuroendocrine Tumor Growth via Targeting VEGFA
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DOI: 10.3389/fendo.2020.566761
Abstract: Background Nonfunctioning pituitary neuroendocrine tumor (NF-PitNET) is difficult to resect. Except for surgery, there is no effective treatment for NF-PitNET. MicroRNA-134 (miR-134) has been reported to inhibit proliferation and invasion ability of tumor cells. Herein,… read more here.
Keywords: invasion; mir 134; level; pitnet ... See more keywords
Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms
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DOI: 10.3389/fendo.2021.791633
Abstract: Pituitary neuroendocrine tumors (PitNET) are commonly benign tumors accounting for 10-25% of intracranial tumors. Prolactin-secreting adenomas represent the most predominant type of all PitNET and for this subtype of tumors, the medical therapy relies on… read more here.
Keywords: pitnet; molecular mechanisms; therapy; resistance ... See more keywords
Case Report: Micro-RNAs in Plasma From Bilateral Inferior Petrosal Sinus Sampling and Peripheral Blood From Corticotroph Pituitary Neuroendocrine Tumors
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DOI: 10.3389/fendo.2022.748152
Abstract: Objective Circulating miRNAs are found in bodily fluids including plasma and can serve as biomarkers for diseases. The aim of this study was to provide the first insight into the landscape of circulating miRNAs in… read more here.
Keywords: pitnet patients; inferior petrosal; acth secreting; pitnet ... See more keywords
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
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DOI: 10.3389/fendo.2023.1129213
Abstract: Introduction Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in… read more here.
Keywords: non functioning; pitnet; functioning pituitary; pituitary neuroendocrine ... See more keywords
A clinicopathological study of non-functioning pituitary neuroendocrine tumours using the World Health Organization 2022 classification
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1368944
Abstract: Background The 2022 World Health Organization (WHO) classification of pituitary neuroendocrine tumour (PitNET) supersedes the previous one in 2017 and further consolidates the role of transcription factors (TF) in the diagnosis of PitNET. Here, we… read more here.
Keywords: classification; world health; 2022 classification; lineage ... See more keywords
Genome wide analysis of circulating miRNAs in growth hormone secreting pituitary neuroendocrine tumor patients’ plasma
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DOI: 10.3389/fonc.2022.894317
Abstract: Background Circulating plasma miRNAs have been increasingly studied in the field of pituitary neuroendocrine tumor (PitNET) research. Our aim was to discover circulating plasma miRNAs species associated with growth hormone (GH) secreting PitNETs versus assess… read more here.
Keywords: pitnet patients; mir 625; patients plasma; pitnet ... See more keywords