Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors
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DOI: 10.1371/journal.pone.0265306
Abstract: Somatic genetic alterations in pituitary neuroendocrine tumors (PitNET) tissues have been identified in several studies, but detection of overlapping somatic PitNET candidate genes is rare. We sequenced and by employing multiple data analysis methods studied… read more here.
Keywords: somatic variants; pitnet; neuroendocrine tumors; pituitary neuroendocrine ... See more keywords
SDF-1α/MicroRNA-134 Axis Regulates Nonfunctioning Pituitary Neuroendocrine Tumor Growth via Targeting VEGFA
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DOI: 10.3389/fendo.2020.566761
Abstract: Background Nonfunctioning pituitary neuroendocrine tumor (NF-PitNET) is difficult to resect. Except for surgery, there is no effective treatment for NF-PitNET. MicroRNA-134 (miR-134) has been reported to inhibit proliferation and invasion ability of tumor cells. Herein,… read more here.
Keywords: invasion; mir 134; level; pitnet ... See more keywords
Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms
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DOI: 10.3389/fendo.2021.791633
Abstract: Pituitary neuroendocrine tumors (PitNET) are commonly benign tumors accounting for 10-25% of intracranial tumors. Prolactin-secreting adenomas represent the most predominant type of all PitNET and for this subtype of tumors, the medical therapy relies on… read more here.
Keywords: pitnet; molecular mechanisms; therapy; resistance ... See more keywords
Case Report: Micro-RNAs in Plasma From Bilateral Inferior Petrosal Sinus Sampling and Peripheral Blood From Corticotroph Pituitary Neuroendocrine Tumors
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DOI: 10.3389/fendo.2022.748152
Abstract: Objective Circulating miRNAs are found in bodily fluids including plasma and can serve as biomarkers for diseases. The aim of this study was to provide the first insight into the landscape of circulating miRNAs in… read more here.
Keywords: pitnet patients; inferior petrosal; acth secreting; pitnet ... See more keywords
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
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DOI: 10.3389/fendo.2023.1129213
Abstract: Introduction Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in… read more here.
Keywords: non functioning; pitnet; functioning pituitary; pituitary neuroendocrine ... See more keywords
Genome wide analysis of circulating miRNAs in growth hormone secreting pituitary neuroendocrine tumor patients’ plasma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.894317
Abstract: Background Circulating plasma miRNAs have been increasingly studied in the field of pituitary neuroendocrine tumor (PitNET) research. Our aim was to discover circulating plasma miRNAs species associated with growth hormone (GH) secreting PitNETs versus assess… read more here.
Keywords: pitnet patients; mir 625; patients plasma; pitnet ... See more keywords
Expression and Clinical Significance of MDM2 in Non-Functioning PitNETs
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DOI: 10.3390/medicina59020373
Abstract: Background and Objective: Non-functioning pituitary neuroendocrine tumors (NF-PitNETs) represent a heterogeneous tumor type that lacks effective medical treatment. MDM2, the main negative regulator of p53, binds to and forms a stable complex with p53 to… read more here.
Keywords: cell; non functioning; mdm2; pitnet ... See more keywords