Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids
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DOI: 10.1038/s41380-020-0807-4
Abstract: Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and degradation, result in a slow-progressing syndrome characterized by cerebellar ataxia, psychotic episodes, and obsessive behavior, as well as cognitive decline.… read more here.
Keywords: pitrm1 knockout; alzheimer disease; pathology; cerebral organoids ... See more keywords