Role of pituitary adenylate cyclase‐activating polypeptide in modulating hypothalamic‐pituitary system
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12094
Abstract: Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a multifunctional peptide that is isolated and identified from the ovine hypothalamus, whose effects and mechanisms have been elucidated in numerous studies. The PACAP and its receptor are widely… read more here.
Keywords: activating polypeptide; cyclase activating; pituitary adenylate; adenylate cyclase ... See more keywords
Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients
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DOI: 10.1007/s12031-017-1025-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated… read more here.
Keywords: heart; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake
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DOI: 10.1016/j.brainres.2019.146626
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) was discovered thirty years ago, but its role in eating and drug use disorders has only recently begun to be investigated. The present review develops the hypothesis that, although PACAP… read more here.
Keywords: intake; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Mechanisms for pituitary adenylate cyclase-activating polypeptide-induced increase in excitability in guinea-pig and mouse adrenal medullary cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172956
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on adrenal medullary (AM) cells as a neurotransmitter of the sympathetic preganglionic nerve. In guinea-pig AM cells, PACAP induces little catecholamine secretion, but enhances secretion evoked by stimulants, whereas… read more here.
Keywords: guinea; guinea pig; pituitary adenylate; adenylate cyclase ... See more keywords
Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents
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DOI: 10.1016/j.neuro.2018.03.010
Abstract: HighlightsPACAP has very potent neuroprotective actions against different neurotoxic agents.We give a summary of the neuroprotective effects against the most commonly used neurotoxic agents, such as 6‐OHDA, MPTP, glutamate and some less well‐known neurotoxic compounds.… read more here.
Keywords: cyclase activating; neuroprotective effects; neurotoxic agents; pituitary adenylate ... See more keywords
Effect of pituitary adenylate cyclase-activating polypeptide-27 on cerebral hemodynamics in healthy volunteers: A 3T MRI study
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2019.170134
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) has emerged as an important signaling peptide in migraine pathogenesis. Recently, we have shown that the less-abundant PACAP isoform, PACAP27, induced migraine and headache in patients equipotently to PACAP38. The… read more here.
Keywords: artery; study; healthy volunteers; pituitary adenylate ... See more keywords
Bombesin, endothelin, neurotensin and pituitary adenylate cyclase activating polypeptide cause tyrosine phosphorylation of receptor tyrosine kinases
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DOI: 10.1016/j.peptides.2020.170480
Abstract: Numerous peptides including bombesin (BB), endothelin (ET), neurotensin (NTS) and pituitary adenylate cyclase-activating polypeptide (PACAP) are growth factors for lung cancer cells. The peptides bind to G protein-coupled receptors (GPCRs) resulting in elevated cAMP and/or… read more here.
Keywords: tyrosine; pituitary adenylate; adenylate cyclase; bombesin endothelin ... See more keywords
Multiple nickel‐sensitive targets elicit cardiac arrhythmia in isolated mouse hearts after pituitary adenylate cyclase‐activating polypeptide‐mediated chronotropy
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.025
Abstract: Graphical abstract Figure. No Caption available. Abstract The pituitary adenylate cyclase‐activating polypeptide (PACAP)‐27 modulates various biological processes, from the cellular level to function specification. However, the cardiac actions of this neuropeptide are still under intense… read more here.
Keywords: cyclase activating; bpm; pacap; pituitary adenylate ... See more keywords
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
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DOI: 10.1021/acs.jmedchem.0c01396
Abstract: Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of known PAC1R ligand scaffolds, PACAP38… read more here.
Keywords: induced increase; maxadilan; cyclase receptor; pituitary adenylate ... See more keywords
Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones
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DOI: 10.1080/10253890.2017.1336535
Abstract: Abstract Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women than men. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these… read more here.
Keywords: pacap; pituitary adenylate; adenylate cyclase; stress ... See more keywords
Pituitary adenylate cyclase‐activating peptide: Potential roles in the pathophysiology and complications of cirrhosis
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DOI: 10.1111/liv.14602
Abstract: Pituitary adenylate cyclase‐activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine,… read more here.
Keywords: cyclase activating; activating peptide; cirrhosis; pituitary adenylate ... See more keywords