Comparative assessment of hypothalamic-pituitary-adrenal axis suppression secondary to intrabursal injection of different glucocorticoids: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-019-01033-6
Abstract: AbstractBackground Hypothalamic-pituitary-adrenal axis (HPAA) suppression is the most common and dangerous, although often unrecognized and untreated, side effect of glucocorticoid administration. The risk and duration depend both on patient and treatment characteristics. High-performance liquid chromatography-tandem… read more here.
Keywords: suppression; hypothalamic pituitary; pituitary adrenal; adrenal axis ... See more keywords
Low-dose ACTH test for evaluation of hypothalamus–pituitary–adrenal axis preoperatively and 3-month follow-up in non-functioning pituitary adenomas
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01292-8
Abstract: Background Peri-operative glucocorticoids are routinely administered to patients undergoing trans-sphenoidal surgery for non-functional pituitary adenomas (NFPA) irrespective of hypothalamus–pituitary–adrenal (HPA) axis status. Purpose Evaluation of HPA axis before and 12 weeks after endoscopic trans-sphenoidal adenomectomy… read more here.
Keywords: cortisol; hypocortisolism; pituitary adenomas; hypothalamus pituitary ... See more keywords
Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2018.04.006
Abstract: Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life… read more here.
Keywords: neuroepigenetic regulation; hpa axis; hypothalamic pituitary; pituitary adrenal ... See more keywords
Pubertal probiotics mitigate lipopolysaccharide-induced programming of the hypothalamic-pituitary-adrenal axis in male mice only
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.09.017
Abstract: Puberty is a period of rapid cortical and neuronal development. Stress exposure during puberty programs the hypothalamic-pituitary-adrenal (HPA) axis responsiveness to future stressors. However, programming can result in an enduring maladaptation of the HPA axis… read more here.
Keywords: hpa axis; axis; hypothalamic pituitary; induced programming ... See more keywords
Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2019.103245
Abstract: Neurolathyrism is a motor neuron disease that is caused by the overconsumption of grass peas (Lathyrus sativus L.) under stressful conditions. The neuro-excitatory β-N-oxalyl-L-α,β-diaminopropionic acid present in grass peas was proposed the causative agent of… read more here.
Keywords: neurolathyrism; hypothalamic pituitary; pituitary adrenal; stress ... See more keywords
Circulating Hypothalamic-Pituitary-Adrenal Axis Hormones and Insulin Concentrations in Horses and Ponies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2021.103810
Abstract: Mechanisms resulting in breed predispositions to insulin dysregulation (ID) are poorly characterized. Cortisol antagonizes insulin, and free, biologically active cortisol can be increased in ID. Breed-related differences in serum free cortisol fraction (FCF) could contribute to… read more here.
Keywords: pituitary adrenal; horses ponies; hypothalamic pituitary; free cortisol ... See more keywords
Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2018.01.011
Abstract: Histories of early life stress (ELS) or social discrimination can reach levels of severity characterized as toxic to mental and physical health. Such toxic social stress during development has been linked to altered acute hypothalamic-pituitary-adrenal… read more here.
Keywords: social stress; axis; hypothalamic pituitary; pituitary adrenal ... See more keywords
Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2016.08.003
Abstract: Elevations in glucocorticoids that result from environmental stressors can have programming effects on brain structure and function when the exposure occurs during sensitive periods that involve heightened neural development. In recent years, adolescence has gained… read more here.
Keywords: translational relevance; hypothalamic pituitary; function stressors; pituitary adrenal ... See more keywords
Childhood parenting and adolescent internalizing and externalizing symptoms: Moderation by multilocus hypothalamic-pituitary-adrenal axis-related genetic variation.
Sign Up to like & getrecommendations! Published in 2022 at "Development and psychopathology"
DOI: 10.1017/s0954579421001620
Abstract: Genetic variants that regulate hypothalamic-pituitary-adrenal (HPA) axis function have been demonstrated to moderate the association between parenting and mental health. However, extant research has focused primarily on (i) effects of individual genes or (ii) maternal… read more here.
Keywords: hypothalamic pituitary; adolescent internalizing; externalizing symptoms; pituitary adrenal ... See more keywords
Adrenal insufficiency in neonates undergoing cardiopulmonary bypass and postoperative hypothalamic-pituitary-adrenal function after prophylactic glucocorticoids
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Perinatology"
DOI: 10.1038/s41372-019-0344-7
Abstract: ObjectivesDetermine incidence of preoperative adrenal insufficiency in neonates >35 weeks gestation with congenital heart disease undergoing cardiothoracic surgery with bypass and effects of prophylactic methylprednisolone on postoperative hypothalamic-pituitary-adrenal function and hemodynamic stability.DesignProspective observational study in… read more here.
Keywords: postoperative hypothalamic; hypothalamic pituitary; insufficiency neonates; adrenal insufficiency ... See more keywords
Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis
Sign Up to like & getrecommendations! Published in 2018 at "Chronobiology International"
DOI: 10.1080/07420528.2018.1498098
Abstract: ABSTRACT Natural glucocorticoids, a class of cholesterol-derived hormones, modulate an array of metabolic, anti-inflammatory, immunosuppressive and cognitive signaling. The synthesis of natural glucocorticoids, largely cortisol in humans, is regulated by the hypothalamic-pituitary-adrenal (HPA) axis and… read more here.
Keywords: administration; hpa axis; axis; hypothalamic pituitary ... See more keywords