MicroRNA-7a2 is required for the development of pituitary stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells and development"
DOI: 10.1089/scd.2022.0023
Abstract: The pituitary gland is inhabited by a subpopulation of SOX2+ stem cells. However, the regulatory mechanisms underlying pituitary stem cell development remain poorly understood. Here, we demonstrate that microRNA-7a (miR-7a) is enriched in the developing… read more here.
Keywords: mir 7a2; stem cell; development; pituitary stem ... See more keywords
Pituitary stem cell regulation by Zeb2 and BMP signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad016
Abstract: Epithelial to mesenchymal transition (EMT) is important for many developing organs, and for wound healing, fibrosis, and cancer. Pituitary stem cells undergo an EMT-like process as they migrate and initiate differentiation, but little is known… read more here.
Keywords: bmp signaling; cell; expression; pituitary stem ... See more keywords
12408 Efnb2 Controls Pituitary Gland Development By Regulating Proliferation Of Pituitary Stem Cells
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1202
Abstract: Abstract Disclosure: A. Gualtieri: None. L. Gomez-Corral: None. J. Nicholson: None. R. Tan: None. L. Guasti: None. C. Gaston-Massuet: None. Efnb2 encodes for the ligand Ephrinb2 that binds to its cognate Eph receptor, which plays… read more here.
Keywords: efnb2; none; stem; pituitary stem ... See more keywords
Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1092063
Abstract: Recently, we discovered that the cytokine interleukin-6 (IL-6) acts as a pituitary stem cell-activating factor, both when administered in vivo and when added to stem cell organoid cultures in vitro. Moreover, its expression, predominantly localized… read more here.
Keywords: cell; stem cell; development; pituitary stem ... See more keywords
Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.43996
Abstract: SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and… read more here.
Keywords: lats yap; yap taz; stem cells; pituitary stem ... See more keywords