Characterization of parainfluenza virus 5 from diarrheic piglet highlights its zoonotic potential.
Sign Up to like & getrecommendations! Published in 2022 at "Transboundary and emerging diseases"
DOI: 10.1111/tbed.14482
Abstract: Parainfluenza virus 5 (PIV5), a member of paramyxoviruses, causes respiratory and neurological infection in several animal species. Whereas information on PIV5 infection in digestive system is very scarce. Here, we successfully isolated one PIV5 strain… read more here.
Keywords: piv5 strain; virus; diarrheic piglet; piv5 ... See more keywords
Genetic Stability of Parainfluenza Virus 5-Vectored Human Respiratory Syncytial Virus Vaccine Candidates after In Vitro and In Vivo Passage
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00559-17
Abstract: ABSTRACT Human respiratory syncytial virus (RSV) is the leading etiologic agent of lower respiratory tract infections in children, but no licensed vaccine exists. Previously, we developed two parainfluenza virus 5 (PIV5)-based RSV vaccine candidates that… read more here.
Keywords: rsv; piv5; vaccine candidates; vaccine ... See more keywords
Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection
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DOI: 10.1128/mbio.00554-20
Abstract: MERS-CoV causes lethal infection in humans, and there is no vaccine. Our work demonstrates that PIV5 is a promising vector for developing a MERS vaccine. Furthermore, success of PIV5-based MERS vaccine can be employed to… read more here.
Keywords: respiratory; middle east; mers cov; single dose ... See more keywords
Relative Contribution of Cellular Complement Inhibitors CD59, CD46, and CD55 to Parainfluenza Virus 5 Inhibition of Complement-Mediated Neutralization
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DOI: 10.3390/v10050219
Abstract: The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work… read more here.
Keywords: mediated neutralization; complement; piv5; complement mediated ... See more keywords