Relationship between MTHFR 677C > T polymorphism and serum PIVKA-II levels in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2025.2493107
Abstract: Abstract Background Hepatocellular carcinoma (HCC) is a major public health problem with increasing incidence and mortality worldwide. The methylenetetrahydrofolate reductase (MTHFR) 677 C > T polymorphism is associated with the development and progression of various tumours, while protein… read more here.
Keywords: serum pivka; hcc; mthfr 677; pivka levels ... See more keywords
Cutoff values of protein induced by vitamin K absence or antagonist II for diagnosing hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030936
Abstract: Protein induced by vitamin K absence or antagonist II (PIVKA-II) is a promising serum marker for hepatocellular carcinoma (HCC). There are limited data on its cutoff value in HCC for Taiwanese cirrhosis patients. This study… read more here.
Keywords: vitamin absence; pivka; cutoff; absence antagonist ... See more keywords
Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-14025-y
Abstract: A significant proportion, ranging from 20 to 40%, of individuals with hepatocellular carcinoma (HCC) do not exhibit elevated Alpha-fetoprotein (AFP) levels. This study aimed to evaluate the utility of serum glypican-3 (GPC3) and protein induced… read more here.
Keywords: serum gpc3; gpc3 pivka; prediction; pivka ... See more keywords
Effect of AFP and PIVKA-II secretion status on prognosis of advanced hepatocellular carcinoma patients receiving TACE combined with systemic therapy
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-15040-9
Abstract: Few biomarkers can predict the effectiveness of transcatheter arterial chemoembolization (TACE) in combination with systemic therapies for patients with advanced hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of changes in alpha-fetoprotein… read more here.
Keywords: tace; advanced hepatocellular; afp pivka; status ... See more keywords
Value of AFP and PIVKA-II in diagnosis of HBV-related hepatocellular carcinoma and prediction of vascular invasion and tumor differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Infectious Agents and Cancer"
DOI: 10.1186/s13027-020-00337-0
Abstract: Background To explore the value of alpha fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HBV-related hepatocellular carcinoma (HCC) and their relationship with vascular invasion, tumor differentiation and… read more here.
Keywords: vascular invasion; pivka; hbv related; afp pivka ... See more keywords
Utility of combining PIVKA-II and AFP in the surveillance and monitoring of hepatocellular carcinoma in the Asia-Pacific region
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Molecular Hepatology"
DOI: 10.3350/cmh.2022.0212
Abstract: Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree… read more here.
Keywords: hepatocellular carcinoma; surveillance; hcc; asia pacific ... See more keywords
Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.726213
Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Due to the lack of efficient tools for early detection, asymptomatic HCC patients are diagnosed at an… read more here.
Keywords: induced vitamin; pivka; hepatocellular carcinoma; vitamin absence ... See more keywords
Long-Term Prognostic Value of AFP and PIVKA-II in HCC After Living Donor Liver Transplantation: A Single-Center Retrospective Study
Sign Up to like & getrecommendations! Published in 2025 at "Transplant International"
DOI: 10.3389/ti.2025.14748
Abstract: Despite the development of numerous prognostic models for hepatocellular carcinoma (HCC) recurrence and mortality after liver transplantation, tumor biomarkers such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II (PIVKA-II) remain widely used in… read more here.
Keywords: afp pivka; hcc; liver transplantation; pivka ... See more keywords
Identification of the Best Cut-Off Value of PIVKA-II for the Surveillance of Patients at Risk of Hepatocellular Carcinoma Development
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12010094
Abstract: Simple Summary The use of tumor biomarkers, although debated, for the surveillance of patients at risk of HCC, is common practice in many clinical centers. Here, we investigated the best cut-off value for one of… read more here.
Keywords: best cut; pivka; cut value; surveillance ... See more keywords
Combined PIVKA II and Vimentin-Guided EMT Tracking in Pancreatic Adenocarcinoma Combined Biomarker-Guided EMT Tracking in PDAC
Sign Up to like & getrecommendations! Published in 2024 at "Cancers"
DOI: 10.3390/cancers16132362
Abstract: Simple Summary Protein Induced by Vitamin K Absence (PIVKA II), also known as Des-γ-Carboxy prothrombin (DCP), is an established tumor marker for hepatocellular carcinoma (HCC) and a good diagnostic performance has also been demonstrated for… read more here.
Keywords: guided emt; emt tracking; pivka vimentin; pivka ... See more keywords
Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13050816
Abstract: Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC. A… read more here.
Keywords: vitamin absence; hepatocellular carcinoma; pivka; meta analysis ... See more keywords