A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Science China Life Sciences"
DOI: 10.1007/s11427-020-1632-5
Abstract: The post-meiotic phase of male germ cell development in mammals undergoes a series of dramatic morphological changes, including acrosome and flagellum formation, nuclear condensation, and cytoplasmic exclusion, which is driven by a highly regulated sequence… read more here.
Keywords: piwi proteins; role; germ cell; piwi ... See more keywords
Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.04.002
Abstract: The Piwi pathway is a conserved gene regulatory mechanism comprised of Piwi-like proteins and Piwi-interacting RNAs, which modulates gene expression via RNA interference and through interaction with epigenetic mechanisms. The mammalian Piwi pathway has been… read more here.
Keywords: fear memory; piwi pathway; contextual fear; piwi ... See more keywords
Two distinct transcriptional controls triggered by nuclear Piwi-piRISCs in the Drosophila piRNA pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2018.06.005
Abstract: Transposons occupy a large proportion of eukaryotic genomes. Spontaneous movement of transposons within the genome leads to genomic mutations that are often life threatening. To avoid such outcomes, host species have acquired an elaborate molecular… read more here.
Keywords: transcriptional controls; triggered nuclear; piwi pirna; nuclear piwi ... See more keywords
Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08803-z
Abstract: PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic elements (transposons). PiRNAs are highly variable in sequence with extensive targeting potential.… read more here.
Keywords: piwi interacting; bias piwi; piwi; nucleotide bias ... See more keywords
Crystal structure of Drosophila Piwi
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14687-1
Abstract: PIWI-clade Argonaute proteins associate with PIWI-interacting RNAs (piRNAs), and silence transposons in animal gonads. Here, we report the crystal structure of the Drosophila PIWI-clade Argonaute Piwi in complex with endogenous piRNAs, at 2.9 Å resolution. A… read more here.
Keywords: crystal structure; structure drosophila; drosophila piwi; piwi ... See more keywords
Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1757896
Abstract: ABSTRACT PIWI homologs constitute a subclass of the Argonaute family. Traditionally, they have been shown to associate with a specific class of small RNAs, piRNAs, to suppress transposable elements and protect genomic integrity in germ… read more here.
Keywords: piwil4; differentiation; role; expression ... See more keywords
Abstract 2456: The PIWI-interacting RNA pathway in prostate is regulated by vitamin D and altered in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2456
Abstract: Low serum vitamin D is a risk factor for aggressive prostate cancer. piRNAs and their interacting partners, PIWI-like (PIWIL) proteins, are aberrantly expressed in many cancers, but few studies have focused on piRNAs in the… read more here.
Keywords: prostate; prostate cancer; pathway; piwi ... See more keywords
piRNA-IPdb: a PIWI-bound piRNAs database to mining NGS sncRNA data and beyond
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08071-6
Abstract: Background PIWI-interacting RNAs (piRNAs) are an abundant single-stranded type of small non-coding RNAs (sncRNAs), which initially were discovered in gonadal cells, with a role as defenders of genomic integrity in the germline, acting against the… read more here.
Keywords: pirna ipdb; ipdb piwi; database; piwi ... See more keywords
Artificial "ping-pong" cascade of PIWI-interacting RNA in silkworm cells.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.058875.116
Abstract: PIWI-interacting RNAs (piRNAs) play essential roles in the defense system against selfish elements in animal germline cells by cooperating with PIWI proteins. A subset of piRNAs is predicted to be generated via the "ping-pong" cascade,… read more here.
Keywords: piwi interacting; pong cascade; artificial ping; piwi ... See more keywords
In vivo PIWI slicing in mouse testes deviates from rules established in vitro
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079349.122
Abstract: Argonautes are small RNA-binding proteins, with some having small RNA-guided endonuclease (slicer) activity that cleaves target nucleic acids. One cardinal rule that is structurally defined is the inability of slicers to cleave target RNAs when… read more here.
Keywords: piwi slicing; established vitro; rules established; mouse ... See more keywords
Novel Perspectives for the Diagnosis and Treatment of Gynecological Cancers using Dysregulation of PIWI Protein and PiRNAs as Biomarkers.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230214101837
Abstract: The term "gynecological cancer" is used for a group of cancers occurring in the female reproductive system. Some of these cancers are ranked as the leading causes of death in developed and developing countries. The… read more here.
Keywords: piwi protein; treatment gynecological; diagnosis treatment; perspectives diagnosis ... See more keywords