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   Articles with "piwi interacting" as a keyword



Oral Piwi‐Interacting RNA Delivery Mediated by Green Tea‐Derived Exosome‐Like Nanovesicles for the Treatment of Aortic Dissection

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202401466

Abstract: Aortic dissection (AD) is a severe cardiovascular disease necessitating active therapeutic strategies for early intervention and prevention. Nucleic acid drugs, known for their potent molecule‐targeting therapeutic properties, offer potential for genetic suppression of AD. Piwi‐interacting… read more here.

Keywords: treatment; aortic dissection; piwi; tea derived ... See more keywords
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PIWI‐interacting RNA 39980 promotes tumor progression and reduces drug sensitivity in neuroblastoma cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.29136

Abstract: Neuroblastoma (NB) is the leading pediatric cancer known for its heterogeneity and clinical aggressiveness leading to chemoresistance. Recent evidence in small RNA research has led to the discovery of PIWI‐interacting RNAs (piRNAs) which work in… read more here.

Keywords: tumor progression; piwi interacting; pir 39980; drug ... See more keywords

PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate

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recommendations! Published in 2021 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2021.103253

Abstract: Background Congenital malformations are common birth defects with high neonatal morbidity and mortality. It is essential to find simpler and more efficient biomarkers for early prenatal diagnosis. Therefore, we investigated PIWI-interacting RNAs (piRNAs) as potential… read more here.

Keywords: piwi interacting; biomarkers early; women carrying; normal foetuses ... See more keywords

Unraveling Disease-Associated PIWI-Interacting RNAs with a Contrastive Learning Methods

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recommendations! Published in 2025 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.5c00173

Abstract: PIWI-interacting RNAs (piRNAs) are a class of small, non-coding RNAs predominantly expressed in the germ cells of animals and play a crucial role in maintaining genomic integrity, mediating transposon suppression, and ensuring gene stability. Beyond… read more here.

Keywords: disease; disease association; pirna disease; contrastive learning ... See more keywords

Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5' to 3' Exoribonucleases.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00007

Abstract: Piwi-interacting RNAs (piRNAs) are a group of small noncoding RNA molecules that regulate the activity of transposons and control gene expression. The cellular concentration of RNAs is generally maintained by their rates of biogenesis and… read more here.

Keywords: piwi interacting; rnas human; interacting rnas; degradation ... See more keywords

Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-08803-z

Abstract: PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic elements (transposons). PiRNAs are highly variable in sequence with extensive targeting potential.… read more here.

Keywords: piwi interacting; bias piwi; piwi; nucleotide bias ... See more keywords

An introduction to PIWI-interacting RNAs (piRNAs) in the context of metazoan small RNA silencing pathways

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recommendations! Published in 2022 at "RNA Biology"

DOI: 10.1080/15476286.2022.2132359

Abstract: ABSTRACT PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to protect genome integrity. Self/nonself discrimination is at the very… read more here.

Keywords: piwi interacting; rna; rnas pirnas; interacting rnas ... See more keywords

PIWI-interacting RNAs in human diseases: databases and computational models

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recommendations! Published in 2022 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbac217

Abstract: PIWI-interacting RNAs (piRNAs) are short 21-35 nucleotide molecules that comprise the largest class of non-coding RNAs and found in a large diversity of species including yeast, worms, flies, plants and mammals including humans. The most… read more here.

Keywords: piwi interacting; computational models; human diseases; databases computational ... See more keywords

The Early Evolution of Tudor Genes in Holozoa and How Their Distribution Was Influenced by Life History Traits in Metazoa

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recommendations! Published in 2025 at "Genome Biology and Evolution"

DOI: 10.1093/gbe/evaf051

Abstract: Abstract Early metazoan evolution was characterized by the expansion of multiple gene families, such as the Tudor family, involved in novel multicellularity-related functions. In eukaryotes, Tudor genes (i.e. genes including at least one Tudor domain)… read more here.

Keywords: tudor; tudor genes; evolution; history ... See more keywords

Prediction of Piwi-Interacting RNAs and Their Functions via Convolutional Neural Network

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recommendations! Published in 2021 at "IEEE Access"

DOI: 10.1109/access.2021.3070083

Abstract: In eukaryotic cells, Piwi-interacting RNAs (piRNAs) are the type of short chain non-coding RNA molecules, which interconnect with PIWI proteins. It performs various cellular and genetic functions such as gene-specific protein translation, expression regulation, maintenance,… read more here.

Keywords: neural network; piwi interacting; interacting rnas; convolutional neural ... See more keywords

Artificial "ping-pong" cascade of PIWI-interacting RNA in silkworm cells.

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recommendations! Published in 2017 at "RNA"

DOI: 10.1261/rna.058875.116

Abstract: PIWI-interacting RNAs (piRNAs) play essential roles in the defense system against selfish elements in animal germline cells by cooperating with PIWI proteins. A subset of piRNAs is predicted to be generated via the "ping-pong" cascade,… read more here.

Keywords: piwi interacting; pong cascade; artificial ping; piwi ... See more keywords