A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Science China Life Sciences"
DOI: 10.1007/s11427-020-1632-5
Abstract: The post-meiotic phase of male germ cell development in mammals undergoes a series of dramatic morphological changes, including acrosome and flagellum formation, nuclear condensation, and cytoplasmic exclusion, which is driven by a highly regulated sequence… read more here.
Keywords: piwi proteins; role; germ cell; piwi ... See more keywords
Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical Implications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.656993
Abstract: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24–31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming… read more here.
Keywords: piwi proteins; potential clinical; piwil1 human; human tumors ... See more keywords
piRNAs and PIWI Proteins as Diagnostic and Prognostic Markers of Genitourinary Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020186
Abstract: piRNAs (PIWI-interacting RNAs) are small non-coding RNAs capable of regulation of transposon and gene expression. piRNAs utilise multiple mechanisms to affect gene expression, which makes them potentially more powerful regulators than microRNAs. The mechanisms by… read more here.
Keywords: genitourinary cancers; piwi proteins; gene expression; diagnostic prognostic ... See more keywords
What Are the Functional Roles of Piwi Proteins and piRNAs in Insects?
Sign Up to like & getrecommendations! Published in 2023 at "Insects"
DOI: 10.3390/insects14020187
Abstract: Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs, exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most complex biogenesis and functional roles. Significant progress has… read more here.
Keywords: insects; piwi proteins; functional roles; pirnas piwi ... See more keywords
The meaning of PIWI proteins in cancer development
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5932
Abstract: Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated… read more here.
Keywords: cancer; proteins cancer; cancer development; piwi proteins ... See more keywords