Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells
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DOI: 10.1080/15476286.2020.1757896
Abstract: ABSTRACT PIWI homologs constitute a subclass of the Argonaute family. Traditionally, they have been shown to associate with a specific class of small RNAs, piRNAs, to suppress transposable elements and protect genomic integrity in germ… read more here.
Keywords: piwil4; differentiation; role; expression ... See more keywords
PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5′ Long Terminal Repeat
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DOI: 10.1128/jvi.01923-19
Abstract: HIV-1 latency is systematically modulated by host factors and viral proteins. During this process, the suppression of HIV-1 transcription plays an essential role in promoting HIV-1 latency. In this study, we found that PIWIL4 repressed… read more here.
Keywords: role; piwil4; hiv; transcription ... See more keywords
A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
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DOI: 10.1182/blood.2022018651
Abstract: RNA-binding proteins (RBPs) form a large and diverse class of factors many members of which are overexpressed in hematological malignancies. RBPs participate in various processes of mRNA metabolism and prevent harmful DNA:RNA hybrids or R-loops.… read more here.
Keywords: function; growth; aml cells; piwil4 ... See more keywords