Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
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DOI: 10.1021/acscentsci.1c01293
Abstract: Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate… read more here.
Keywords: pixatimod; potently inhibits; pixatimod pg545; heparan sulfate ... See more keywords
A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours
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DOI: 10.1038/s41416-018-0006-0
Abstract: BackgroundPG545 (pixatimod) is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models.MethodsThis Phase I study investigated the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of… read more here.
Keywords: immunomodulatory agent; advanced solid; pixatimod; phase study ... See more keywords