Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z.
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DOI: 10.1053/j.gastro.2022.03.010
Abstract: BACKGROUND AND AIMS Insulin signaling is known to regulate essential proteostasis mechanisms. METHODS The analyses here examined effects of insulin-signaling in the PiZ mouse model of α1-antitrypsin deficiency (ATD) in which hepatocellular accumulation and proteotoxicity… read more here.
Keywords: piz lirko; mice; insulin signaling; piz ... See more keywords