RIIβ‐PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205173
Abstract: The RIIβ subunit of cAMP‐dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. RIIβ‐knockout mice show leanness and increased UCP1 in brown adipose tissue. The authors have previously reported that RIIβ… read more here.
Keywords: dmh gabaergic; wat browning; gabaergic neurons; pka ... See more keywords
Influence of the pKa value on the antioxidant activity of licorice flavonoids under solvent‐mediated effects
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200470
Abstract: Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to their significant antioxidant activities. However, the molecular mechanism of their antioxidant activity remains unclear. Therefore, network pharmacology, ADMET, density functional… read more here.
Keywords: antioxidant activity; pharmacology; pka; activity ... See more keywords
Fat mass and obesity‐associated protein alleviates Aβ1–40 induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11959
Abstract: Amyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular degeneration (AMD). Aβ induces inflammatory responses in RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A)… read more here.
Keywords: degeneration; pka; rpe degeneration; retinal pigment ... See more keywords
CE determination of the thermodynamic pKa values and limiting ionic mobilities of 14 low molecular mass UV absorbing ampholytes for accurate characterization of the pH gradient in carrier ampholytes‐based IEF and its numeric simulation
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900381
Abstract: Fourteen low molecular mass UV absorbing ampholytes containing 1 or 2 weakly acidic and 1 or 2 weakly basic functional groups that best satisfy Rilbe's requirement for being good carrier ampholytes (ΔpKa = pKamonoanion ‒… read more here.
Keywords: values limiting; pka values; limiting ionic; pka ... See more keywords
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB Life"
DOI: 10.1002/iub.2714
Abstract: Although Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co‐discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP‐dependent protein kinase (PKA), but also by… read more here.
Keywords: protein kinase; pka; pki; inhibitor ... See more keywords
Prediction of acid pKa values in the solvent acetone based on COSMO‐RS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26864
Abstract: In this contribution we extent the use of the conductor‐like screening model for realistic solvation (COSMO‐RS) to the prediction of pKa values in acetone, a commonly used dipolar aprotic solvent. For this, we calculated the… read more here.
Keywords: prediction acid; cosmo prediction; pka; pka values ... See more keywords
Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7658
Abstract: Chronic traumatic stress results in various psychiatric disorders, especially posttraumatic stress disorder (PTSD). Previous study demonstrated that curculigoside (CUR) a component of Rhizoma Curculiginis prevented fear extinction and stress‐induced depression‐like behaviors. However, its effects on… read more here.
Keywords: pka signaling; signaling pathway; cur; pka ... See more keywords
New Insight into Carboxylic Acid Metabolisms and pH Regulations During Insoluble Phosphate Solubilisation Process by Penicillium oxalicum PSF-4.
Sign Up to like & getrecommendations! Published in 2020 at "Current microbiology"
DOI: 10.1007/s00284-020-02238-2
Abstract: Phosphate solubilising fungi (PSF) play an important role in increasing phosphorus (P) bioavailability and the fertility of soil. However, the mechanism by which PSF solubilise insoluble P using carboxylic acid is not fully understood. In… read more here.
Keywords: solubilisation; carboxylic acid; pka; oxalicum psf ... See more keywords
Correlation between the pKa and nuclear shielding of α-hydrogen of ketones
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4244-8
Abstract: The α-H acidity is an important chemical property of ketones that has attracted much research interest. Theoretical prediction of pKa for ketone α-H is significant. In this work, we theoretically studied the nuclear shielding of… read more here.
Keywords: calculated nuclear; pka values; enol forms; correlation ... See more keywords
Absolute and relative pKa predictions via a DFT approach applied to the SAMPL6 blind challenge
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0150-x
Abstract: In this work, quantum mechanical methods were used to predict the microscopic and macroscopic pKa values for a set of 24 molecules as a part of the SAMPL6 blind challenge. The SMD solvation model was… read more here.
Keywords: pka units; blind challenge; sampl6 blind; pka ... See more keywords
pKa measurements for the SAMPL6 prediction challenge for a set of kinase inhibitor-like fragments
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0168-0
Abstract: Determining the net charge and protonation states populated by a small molecule in an environment of interest or the cost of altering those protonation states upon transfer to another environment is a prerequisite for predicting… read more here.
Keywords: challenge; pka prediction; pka; protonation states ... See more keywords