FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry
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DOI: 10.1016/j.celrep.2020.108266
Abstract: SUMMARY Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity… read more here.
Keywords: pka spark; rgg; rna binding; pka activity ... See more keywords