LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "pka activity" as a keyword



FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry

Sign Up to like & get
recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.108266

Abstract: SUMMARY Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity… read more here.

Keywords: pka spark; rgg; rna binding; pka activity ... See more keywords

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Sign Up to like & get
recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-66504-2

Abstract: Loss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11, we conduct multi-omic and neurobiological analyses of Akap11 mutant… read more here.

Keywords: pka activity; disorder; mutant mice; akap11 mutant ... See more keywords

Selective HDAC6 inhibitor WT161 modulates the VLA-4/FAK pathway by inhibiting PKA activity in acute lymphoblastic leukemia

Sign Up to like & get
recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-23887-y

Abstract: Acute lymphoblastic leukemia (ALL) is a genetically heterogeneous malignancy often associated with poor prognosis due to chemotherapy resistance and relapse. Histone deacetylase (HDAC) inhibitors represent an emerging class of epigenetic antitumor drugs. Among them, HDAC6,… read more here.

Keywords: pka activity; selective hdac6; acute lymphoblastic; lymphoblastic leukemia ... See more keywords

A versatile kinase mobility shift assay (KiMSA) for PKA analysis and cyclic AMP detection in sperm physiology (and beyond)

Sign Up to like & get
recommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2024.1356566

Abstract: The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments… read more here.

Keywords: pka activity; physiology; pka; kinase ... See more keywords