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Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174370
Abstract: Colorectal cancer (CRC) is the most fatal gastrointestinal tumor and it is urge to explore powerful drugs for the treatment. Diosgenin (DSG) as a new steroidal had been reported exerts anti-tumor activity in multiple cancers,…
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Keywords:
colorectal cancer;
crc;
pka creb;
camp pka ... See more keywords
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Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104537
Abstract: Alzheimer's disease (AD) is an important chronic neurodegenerative disorder and is mainly associated with cognitive dysfunction. At present, bioactive compounds from traditional medicinal plants have received much attention for the enhancement of cognitive function. Danshensu,…
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Keywords:
cognitive impairments;
pka creb;
scopolamine amyloid;
induced cognitive ... See more keywords
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Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)60033-4
Abstract: Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and…
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Keywords:
camp;
taurochenodeoxycholic acid;
signaling pathway;
tgr5 receptor ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33352-8
Abstract: Melanogenesis is the process of production of melanin pigments that are responsible for the colors of skin, eye, and hair and provide protection from ultraviolet radiation. However, excessive levels of melanin formation cause hyperpigmentation disorders…
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Keywords:
pka creb;
melanogenesis;
camp pka;
p38 mapk ... See more keywords
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Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15751
Abstract: Postoperative cognitive dysfunction (POCD) is a prevalent disorder after anaesthesia in the elderly patients. Roflumilast (RF), a phosphodiesterase 4 (PDE‐4) inhibitor, could improve cognition with no side effects. Here, we sought to explore the efficacy…
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Keywords:
pka creb;
creb mek;
mek erk;
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Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14586
Abstract: Recent investigations have shown that the Rab family of GTPases is associated with all aspects of melanogenesis. However, the effect of Rab23, which localizes to the plasma membrane and regulates the endocytic pathway within eukaryotic…
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Keywords:
pka creb;
rab23;
induced melanogenesis;
downregulation ... See more keywords
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Published in 2023 at "Photochemistry and photobiology"
DOI: 10.1111/php.13813
Abstract: Intrauterine adhesion (IUA), a major cause of uterine infertility, is pathologically characterized by endometrial fibrosis. Current treatments for IUA have poor efficacy with high recurrence rate, and restoring uterine functions is difficult. We aimed to…
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Keywords:
pka creb;
pbm;
therapy;
camp pka ... See more keywords
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Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2812839
Abstract: Background Excitotoxicity plays a key role in nervous system disease and can trigger a critical cascade of reaction which affects cell viability and promotes neuronal death. Tetramethylpyrazine (TMP) reveals its effect in the treatment of…
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Keywords:
signaling pathway;
tetramethylpyrazine;
pka creb;
concentration ... See more keywords
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Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4455654
Abstract: Cerebral microinfarcts (CMIs) are characterized by sporadic obstruction of small vessels leading to neurons death. They are associated with increased risk of cognitive impairments and may have different risk factors compared with macroinfarcts. CMIs have…
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Keywords:
pka creb;
activation pka;
byhw decoction;
cerebral microinfarcts ... See more keywords
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Published in 2021 at "Stroke"
DOI: 10.1161/strokeaha.120.033285
Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Neuronal pyroptosis is a type of regulated cell death triggered by proinflammatory signals. CCR5 (C-C chemokine receptor 5)-mediated inflammation is involved in the pathology…
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Keywords:
neuronal pyroptosis;
pka creb;
ccr5;
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Published in 2019 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902019000218300
Abstract: Icariin, a prenylated flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for osteoporosis. The present study aimed to clarify the detailed molecular mechanisms of action of icariin on osteoblast function,…
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Keywords:
creb;
camp pka;
pka creb;
icariin ... See more keywords