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   Articles with "pka pathway" as a keyword



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Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway‐dependent manner in budding yeast

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14567

Abstract: Previously, we showed that an aberrant accumulation of activated Ras in mitochondria correlates with an increase in apoptosis. In this article, we show that lack of trehalose‐6P‐synthase, known to trigger apoptosis in Saccharomyces cerevisiae, induces localization… read more here.

Keywords: active ras2; pka pathway; regulated cell; mitochondria ... See more keywords
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Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells

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recommendations! Published in 2017 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2016.10.008

Abstract: In human adrenal, serotonin (5-HT), produced by mast cells located in zona glomerulosa, stimulates production of corticosteroids through a paracrine mechanism involving the 5-HT receptor type 4 (5-HT4). The aim of the present study was… read more here.

Keywords: adrenocortical cells; human adrenocortical; type calcium; calcium ... See more keywords
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Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis

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recommendations! Published in 2022 at "Journal of Immunology Research"

DOI: 10.1155/2022/2291877

Abstract: Endoplasmic reticulum stress (ER stress) contributes to the development of pulmonary fibrosis, especially in type II alveolar epithelial cells (AECs) apoptosis. ER stress also promotes NLRP3 inflammasome activation which is inhibited by upregulation of cAMP/PKA… read more here.

Keywords: stress; pka pathway; nlrp3 inflammasome; camp pka ... See more keywords
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Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae

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recommendations! Published in 2017 at "Microbial Cell"

DOI: 10.15698/mic2017.03.561

Abstract: Multiple types of nutrient transceptors, membrane proteins that combine a transporter and receptor function, have now been established in a variety of organisms. However, so far all established transceptors utilize one of the macronutrients, glucose,… read more here.

Keywords: zinc; pka pathway; iron zinc; zrt1 ... See more keywords
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The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1176443

Abstract: Introduction: The global prevalence of obesity is rising rapidly. Conversion of white adipose tissue (WAT) into beige adipose tissue with heat-consuming characteristics, i.e., WAT browning, effectively inhibits obesity. Dai-Zong-Fang (DZF), a traditional Chinese medicine formula,… read more here.

Keywords: dai zong; expression; pka pathway; obesity ... See more keywords
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The role of LRRK2 on PKA-NFκB pathway in microglia cells: implications for Parkinson’s disease

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recommendations! Published in 2019 at "Neural Regeneration Research"

DOI: 10.4103/1673-5374.257523

Abstract: Leucine-rich repeat kinase 2 (LRRK2), a gene linked to autosomal-dominantly inherited and sporadic Parkinson’s disease (PD) as a risk factor, encodes a large and complex protein with a dual enzymatic activity. LRRK2 contains several domains… read more here.

Keywords: role lrrk2; lrrk2 pka; microglia; parkinson disease ... See more keywords
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miR-155-5p Promotes Dorsal Root Ganglion Neuron Axonal Growth in an Inhibitory Microenvironment via the cAMP/PKA Pathway

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recommendations! Published in 2019 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.31904

Abstract: Sensory dysfunction post spinal cord injury causes patients great distress. Sciatic nerve conditioning injury (SNCI) has been shown to restore sensory function after spinal cord dorsal column injury (SDCL); however, the underlying mechanism of this… read more here.

Keywords: growth; mir 155; camp pka; via camp ... See more keywords