Treatment Responsiveness of Parkinsonism in Atypical Pantothenate Kinase‐Associated Neurodegeneration
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DOI: 10.1002/mdc3.13056
Abstract: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare progressive autosomal recessive disease caused by mutations in the PANK2 gene. PANK2 encodes a pantothenate kinase, an enzyme involved in coenzyme A production. The clinical presentation of PKAN… read more here.
Keywords: pantothenate kinase; pkan; kinase associated; associated neurodegeneration ... See more keywords
Clinical course of patients with pantothenate kinase-associated neurodegeneration (PKAN) before and after DBS surgery
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DOI: 10.1007/s00415-019-09499-3
Abstract: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disorder with a progressive clinical course. In addition to symptomatic therapy, DBS has been increasingly recognized as a potential therapeutic strategy, especially in severe cases. Therefore,… read more here.
Keywords: improvement; pantothenate kinase; pkan; dbs ... See more keywords
F147. RESTING STATE NETWORKS ALTERATION IN PANTOTHENATE-KINASE ASSOCIATED NEURODEGENERATION (PKAN)
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DOI: 10.1093/schbul/sby017.678
Abstract: Abstract Background While functional MRI and PET studies have shown altered task-related brain activity in PKAN, we want to find such differences also in the resting state (RS). Here we used ICA based analysis to… read more here.
Keywords: pkan; fronto parietal; connectivity; state networks ... See more keywords