Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish
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DOI: 10.3390/biom8040153
Abstract: Patients with inherited dilated cardiomyopathy (DCM) often suffer from severe heart failure based on impaired cardiac contractility leading to increased morbidity and mortality. Integrin-linked kinase (ILK) as a part of the cardiac mechanical stretch sensor… read more here.
Keywords: deficient zebrafish; pkb phosphorylation; ilk; ilk deficient ... See more keywords