TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14599
Abstract: The plasticity of proximal tubular epithelial cells in response to TGFβ contributes to the expression of TWIST1 to drive renal fibrosis. The mechanism of TWIST1 expression is not known. We show that both PI3 kinase… read more here.
Keywords: cell; proximal tubular; expression; twist1 expression ... See more keywords
Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia‐derived cells: Role of PKCβ
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000062
Abstract: In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia‐derived cell line, CCRF‐CEM. On the basis of the structural features… read more here.
Keywords: cell acute; lymphoblastic leukemia; acute lymphoblastic; leukemia derived ... See more keywords
Role of PLD−PKCζ signaling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11145
Abstract: We sought to determine the mechanism by which angiotensin II (ANGII) stimulates NADPH oxidase‐mediated superoxide (O2.−) production in bovine pulmonary artery smooth muscle cells (BPASMCs). ANGII‐induced increase in phospholipase D (PLD) and NADPH oxidase activities… read more here.
Keywords: oxidase; pkc; pld; angii induced ... See more keywords
Estimation of PKCδ autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biophotonics"
DOI: 10.1002/jbio.201500332
Abstract: Golgi apparatus (GA) is a center for lipid metabolism and the final target of ceramide pathway, which may result in apoptosis. In this work localization of highly hydrophobic hypericin is followed by time-resolved imaging of… read more here.
Keywords: u87 glioma; pkc autophosphorylation; s645 pkc; glioma cells ... See more keywords
Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23236
Abstract: Increasing evidence suggests that disruption of neuron activity contributes to the autistic phenotype. Thus, we aimed in this study to explore the role of protein kinase C beta (PKCβ) in the regulation of neuron activity… read more here.
Keywords: fto; protein; like behavior; autism like ... See more keywords
Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose‐Exposed Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25785
Abstract: Hyperglycemia leads to excess reactive oxygen species (ROS) generation, which causes many diabetic complications, such as cardiomyopathy. Nuclear factor erythroid 2‐related factor 2 (Nrf2), a redox‐sensing transcription factor, can up‐regulate its downstream antioxidant gene expressions… read more here.
Keywords: high glucose; activation; pkc; cell ... See more keywords
Protein kinase Cε targets respiratory chain and mitochondrial membrane potential but not F0F1‐ATPase in renal cells injured by oxidant
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27256
Abstract: We have previously shown that protein kinase Cε (PKCε) is involved in mitochondrial dysfunction in renal proximal tubular cells (RPTC). This study examined mitochondrial targets of active PKCε in RPTC injured by the model oxidant… read more here.
Keywords: atp; f0f1 atpase; protein kinase; pkc ... See more keywords
Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23868
Abstract: Type 5 metabotropic glutamate receptors (mGluR5) activate protein kinase C (PKC) via coupling to Gαq/11 protein signaling. We have previously demonstrated that the epsilon isoform of PKC (PKCɛ) is a critical downstream target of mGluR5… read more here.
Keywords: pkc; mglur5 surface; mglur5; surface expression ... See more keywords
Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7313
Abstract: Herein, apoptotic mechanism of Moracin D was explored in prostate cancer cells in association with peroxisome proliferator‐activated receptor gamma (PPAR‐γ)‐related signaling involved in lipid metabolism. Moracin D augmented cytotoxicity and sub G1 population in PC3… read more here.
Keywords: cancer cells; pkc; moracin; du145 cells ... See more keywords
The roles of PKCs in regulating autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2731-4
Abstract: PurposeAutophagy, as a highly conserved cellular degradation and recycling process, plays an important part in maintaining cellular homeostasis. PKC signaling is involved in multiple pathways including cell cycle progression, tumorigenesis, migration and autophagy.MethodsLiteratures about PKC… read more here.
Keywords: roles pkcs; regulating autophagy; pkcs regulating; autophagy ... See more keywords
Aflatoxin-induced upregulation of protein arginine methyltransferase 5 is mediated by protein kinase C and extracellular signal-regulated kinase
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-018-9439-8
Abstract: Aflatoxins are fungal metabolites classified into four major groups such as B1, B2, G1, and G2. These natural aflatoxins are designated as group I carcinogen by the International Agency for Research on Cancer. Among these,… read more here.
Keywords: arginine methyltransferase; kinase; extracellular signal; protein arginine ... See more keywords