The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102813
Abstract: Background Preeclampsia is a devastating hypertensive disorder of pregnancy with unknown mechanism. Recent studies have considered abnormal autophagy as a new cellular mechanism for this disorder, while little is known about how autophagy is specifically… read more here.
Keywords: pkc inhibition; inhibition; pathogenesis; preeclampsia ... See more keywords
Evidence that PKCα inhibition in Dalton's Lymphoma cells augments cell cycle arrest and mitochondrial-dependent apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia research"
DOI: 10.1016/j.leukres.2021.106772
Abstract: Protein kinase Cα (PKCα), belonging to ser/thr protein kinase, perform various biological functions. Overexpression of PKCα has been observed in multiple human malignancies including lymphoma. However, the molecular pathogenesis and involvement of PKCα in Non-Hodgkin… read more here.
Keywords: dependent apoptosis; mitochondrial dependent; lymphoma; pkc inhibition ... See more keywords
Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28512-9
Abstract: Upregulation of Ca2+-permeable AMPA receptors (CP-AMPARs) in dorsal horn (DH) neurons has been causally linked to persistent inflammatory pain. This upregulation, demonstrated for both synaptic and extrasynaptic AMPARs, depends on the protein kinase C alpha… read more here.
Keywords: spinal pkc; synapses primary; pkc inhibition; pain ... See more keywords
Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.997013
Abstract: Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that… read more here.
Keywords: time; inhibition; time dependent; high glucose ... See more keywords