Identification of good and bad fragments of tricyclic triazinone analogues as potential PKC-θ inhibitors through SMILES–based QSAR and molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01629-2
Abstract: Based on the mechanism of action of PKC-θ, the inhibition of this enzyme is considered a potential target for the treatment of autoimmune diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis.… read more here.
Keywords: potential pkc; triazinone analogues; pkc inhibitors; pkc ... See more keywords
Assessment of PKA and PKC inhibitors on force and kinetics of non‐failing and failing human myocardium
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DOI: 10.1016/j.lfs.2018.10.065
Abstract: Aims: Heart failure (HF) is a prevalent disease that is considered the foremost reason for hospitalization in the United States. Most protein kinases (PK) are activated in heart disease and their inhibition has been shown… read more here.
Keywords: non failing; pkc inhibitors; pka pkc; failing failing ... See more keywords
Insights into the structural requirements of PKCζ inhibitors as potential anti-arthritis agents based on 3D-QSAR, homology modeling and docking approach
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DOI: 10.1016/j.molstruc.2021.131148
Abstract: Abstract Protein Kinase C ζ (PKCζ) has emerged as a promising novel drug target for the treatment of arthritis. A series of isoquinoline PKCζ inhibitors were analyzed through CoMFA, CoMSIA, homology modeling, and molecular docking… read more here.
Keywords: structural requirements; homology modeling; insights structural; pkc inhibitors ... See more keywords
FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma
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DOI: 10.3390/cancers15082280
Abstract: Simple Summary Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Despite efficient control of the primary tumor by radiation or surgery, up to 50% of patients subsequently develop metastases, mainly… read more here.
Keywords: fak; fak inhibitor; mek; pkc inhibitors ... See more keywords