Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
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DOI: 10.1126/scitranslmed.adk8096
Abstract: Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circuits remains unclear. To investigate this… read more here.
Keywords: pkc interneurons; pain hypersensitivity; pain; neuropathic pain ... See more keywords