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Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26451
Abstract: Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc and cartilage with the ability to resist compressive loads. Aggrecan degradation in…
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Keywords:
pkc p38;
glucose enhances;
aggrecan expression;
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01171-y
Abstract: The penicillinase-resistant antibiotics (PRAs), especially the highly prescribed flucloxacillin, caused frequent liver injury via mechanisms that remain largely non-elucidated. We first showed that flucloxacillin, independently of cytotoxicity, could exhibit cholestatic effects in human hepatocytes in…
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Keywords:
pkc p38;
hsp27 activation;
pi3k akt;
activation ... See more keywords