FRETting over postsynaptic PKC signaling
Sign Up to like & getrecommendations! Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0190-5
Abstract: Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin… read more here.
Keywords: postsynaptic pkc; pkc signaling; fretting postsynaptic;
The Pellino1-PKCθ signaling axis is an essential target for improving anti-tumor CD8+ T-lymphocyte function.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0419
Abstract: CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a… read more here.
Keywords: function; cd8; peli1; pkc signaling ... See more keywords
MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-lb087
Abstract: Abstract Dysregulated actions of the bone-derived phosphaturic hormone FGF23 result in several inherited diseases and contribute substantially to the morbidity and mortality in renal failure. Molecular mechanisms governing FGF23 production are poorly defined. Parathyroid hormone… read more here.
Keywords: per group; pth; pkc; fgf23 ... See more keywords
The Emerging Key Role of the mGluR1-PKCγ Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169169
Abstract: Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal dominantly inherited progressive disorders with degeneration and dysfunction of the cerebellum. Although different subtypes of SCAs are classified according to the disease-associated causative genes, the clinical… read more here.
Keywords: spinocerebellar ataxias; signaling pathway; role; mglur1 pkc ... See more keywords