micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.074
Abstract: Gemcitabine sensitization is important for the treatment of pancreatic cancer. We have previously shown that DNA-dependent protein kinase catalytic subunit (DNA-PKcs) over-expression causes Akt activation and gemcitabine resistance in pancreatic cancer cells. Here, we aim… read more here.
Keywords: pancreatic cancer; pkcs; mir 101; dna pkcs ... See more keywords
DNA-PKcs suppresses illegitimate chromosome rearrangements
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1101/2023.12.30.573736
Abstract: Two DNA repair pathways, non-homologous end joining (NHEJ) and alternative end joining (A-EJ), are involved in V(D)J recombination and chromosome translocation. Previous studies reported distinct repair mechanisms for chromosome translocation, with NHEJ involved in human… read more here.
Keywords: dna pkcs; pkcs inhibition; chromosome; pkcs ... See more keywords
Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells
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DOI: 10.18632/oncotarget.16073
Abstract: The current study tested the anti-hepatocellular carcinoma (HCC) cell activity of TIC10, a first-in-class small-molecule tumor necrosis (TNF)-related apoptosis-inducing ligand (TRAIL) inducer. TIC10 exerted potent anti-proliferative and pro-apoptotic actions in primary and established human HCC… read more here.
Keywords: hepatocellular carcinoma; factor tic10; dna pkcs; resistance factor ... See more keywords