A Woman With “Polycystic Kidney Disease”
Sign Up to like & getrecommendations! Published in 2020 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2020.05.026
Abstract: INTRODUCTION P olycystic kidney disease (PKD) is a hereditary disease that is usually caused by PKD1 or PKD2 pathogenic mutation and that can be divided into 2 types by heredity. When symptoms present neonatally, the… read more here.
Keywords: pkd; disease; polycystic kidney; tsc ... See more keywords
Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220496
Abstract: Polycystic kidney disease (PKD) is an inherited disorder that results in large kidneys, numerous fluid-filled cysts, and ultimately end-stage kidney disease. PKD is either autosomal dominant caused by mutations in PKD1 or PKD2 genes or… read more here.
Keywords: notch signaling; kidney; overexpression; pkd ... See more keywords
#2416 Bicc1 and PKD: linking RNA metabolism to kidney disease
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.236
Abstract: Mutations in PKD1 or PKD2 lead to autosomal dominant polycystic kidney disease (PKD) by allowing urine flow-sensing primary cilia to activate tissue growth signals. However, the responsible cilia-associated factors and a strategy to block them… read more here.
Keywords: kidney disease; bicc1; target mrnas; pkd ... See more keywords
A brown trout ( Salmo trutta ) population faces devastating consequences due to proliferative kidney disease and temperature increase: A case study from Austria
Sign Up to like & getrecommendations! Published in 2019 at "Ecology of Freshwater Fish"
DOI: 10.1111/eff.12528
Abstract: Proliferative kidney disease (PKD) is an emerging parasitic disease that affects wild and farmed salmonid fishes worldwide. Currently, it is widespread in Europe with records in many countries. This study assessed the status of PKD… read more here.
Keywords: pkd; brown trout; disease; proliferative kidney ... See more keywords
Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B‐independent signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14131
Abstract: Members of the protein kinase D (PKD) family of serine/threonine kinases are known to exert diverse roles in neuronal stress responses. Here, we show the transient activation and nuclear translocation of endogenous PKD upon oxidative… read more here.
Keywords: pkd; stress; factor kappa; protein kinase ... See more keywords
Genetic and phenotypic analyses of PRRT2 positive and negative paroxysmal kinesigenic dyskinesia
Sign Up to like & getrecommendations! Published in 2024 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864231224110
Abstract: Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder, characterized by attacks of involuntary movements triggered by sudden action. Variants in proline-rich transmembrane protein 2 (PRRT2) are the most common genetic cause of PKD.… read more here.
Keywords: paroxysmal kinesigenic; pkd patients; prrt2 variants; pkd ... See more keywords
Neurogenic differentiation 2 promotes inflammatory activation of macrophages in doxorubicin-induced myocarditis via regulating protein kinase D
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-025-04626-7
Abstract: Although it has been established that protein kinase D (PKD) plays a crucial role in various diseases, its precise role in myocarditis remains elusive. To investigate PKD’s involvement in myocarditis, we established a mouse model… read more here.
Keywords: protein kinase; induced myocarditis; heart tissues; pkd ... See more keywords
Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0248668
Abstract: Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions. Protein kinase D… read more here.
Keywords: nlrp3 inflammasome; pkd; auto phosphorylation; activation ... See more keywords
Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15123
Abstract: Obesity increases cancer risk including breast cancer (BC). However, the direct regulatory mechanisms by which obesity promotes BC progression remain largely unknown. We show that lysophosphatidic acid/protein kinase D1 (LPA/PKD-1)-CD36 signaling is a bona fide… read more here.
Keywords: pkd; breast cancer; lpa pkd; cancer ... See more keywords
Comparative study of proliferative kidney disease in grayling Thymallus thymallus and brown trout Salmo trutta fario: an exposure experiment.
Sign Up to like & getrecommendations! Published in 2017 at "Diseases of aquatic organisms"
DOI: 10.3354/dao03102
Abstract: Proliferative kidney disease (PKD) is an emerging disease threatening wild salmonid populations, with the myxozoan parasite Tetracapsuloides bryosalmonae as the causative agent. Species differences in parasite susceptibility and disease-induced mortality seem to exist. The aim… read more here.
Keywords: pkd; trout; brown trout; histopathology ... See more keywords