Primary cilia control endothelial permeability by regulating expression and location of junction proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab165
Abstract: AIMS Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair… read more here.
Keywords: junction; endothelial permeability; pkd patients; primary cilia ... See more keywords
Genetic and phenotypic analyses of PRRT2 positive and negative paroxysmal kinesigenic dyskinesia
Sign Up to like & getrecommendations! Published in 2024 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864231224110
Abstract: Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder, characterized by attacks of involuntary movements triggered by sudden action. Variants in proline-rich transmembrane protein 2 (PRRT2) are the most common genetic cause of PKD.… read more here.
Keywords: paroxysmal kinesigenic; pkd patients; prrt2 variants; pkd ... See more keywords
Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116243
Abstract: Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system is involved in feeding, sleep, and pressure regulation. Recently, orexin-A levels have been found to… read more here.
Keywords: orexin levels; pkd patients; kidney disease; patients affected ... See more keywords