Protein kinase D1 inhibition interferes with mitosis progression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28651
Abstract: Protein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, very… read more here.
Keywords: mitosis progression; pkd1; mitosis; protein kinase ... See more keywords
Adipose-Specific Knockout of Protein Kinase D1 Suppresses de novo Lipogenesis in Mice via SREBP1c-dependent Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112548
Abstract: Having healthy adipose tissue is essential for metabolic health, as excessive adipose tissue in the body can cause its dysregulation and driving chronic metabolic diseases. Protein kinase D1 (PKD1) is considered to be a key… read more here.
Keywords: pkd1; novo lipogenesis; lipogenesis; adipose tissue ... See more keywords
Pkd1-targeted mutation reveals a role for the Wolffian duct in autosomal dominant polycystic kidney disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174419000436
Abstract: Abstract Several life-threatening diseases of the kidney have their origins in mutational events that occur during embryonic development. In this study, we investigate the role of the Wolffian duct (WD), the earliest embryonic epithelial progenitor… read more here.
Keywords: autosomal dominant; wolffian duct; pkd1; disease ... See more keywords
Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abd0033
Abstract: Social memory enables one to recognize and distinguish specific individuals. It is fundamental to social behaviors that can be mediated by the oxytocin receptor (OXTR), such as forming relationships. We investigated the molecular regulation and… read more here.
Keywords: social memory; pkd1; oxytocin receptor; phosphorylation ... See more keywords
Autosomal dominant polycystic kidney disease in absence of renal cyst formation illustrates genetic interaction between WT1 and PKD1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2019-106633
Abstract: Purpose Autosomal dominant polycystic kidney disease (ADPKD), caused by pathogenic variants of either PKD1 or PKD2, is characterised by wide interfamilial and intrafamilial phenotypic variability. This study aimed to determine the molecular basis of marked… read more here.
Keywords: pkd1; disease; wt1; autosomal dominant ... See more keywords
Mutation Analysis of PKD1 and PKD2 Genes in a Large Italian Cohort Reveals Novel Pathogenic Variants Including A Novel Complex Rearrangement.
Sign Up to like & getrecommendations! Published in 2023 at "Nephron"
DOI: 10.1159/000530657
Abstract: BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease of the kidney. It occurs in adulthood but is also rarely diagnosed in early childhood. The majority of the disease-causing variants observed… read more here.
Keywords: disease; pkd1 pkd2; mutation analysis; pkd1 ... See more keywords
Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0226145
Abstract: Toll-like receptor (TLR) signaling can contribute to the pathogenesis of arthritis. Disruption of TLR signaling at early stages of arthritis might thereby provide an opportunity to halt the disease progression and ameliorate outcomes. We previously… read more here.
Keywords: induced arthritis; pkd1; ameliorating effects; tlr ... See more keywords
Recessive PKD1 Mutations Are Associated With Febrile Seizures and Epilepsy With Antecedent Febrile Seizures and the Genotype-Phenotype Correlation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.861159
Abstract: Objective The PKD1 encodes polycystin-1, a large transmembrane protein that plays important roles in cell proliferation, apoptosis, and cation transport. Previous studies have identified PKD1 mutations in autosomal dominant polycystic kidney disease (ADPKD). However, the… read more here.
Keywords: antecedent febrile; pkd1; seizures epilepsy; epilepsy antecedent ... See more keywords
PKD1 Nonsense Variant in a Lagotto Romagnolo Family with Polycystic Kidney Disease
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061210
Abstract: A female Lagotto Romagnolo dog with polycystic kidney disease (PKD) and her progeny, including PKD-affected offspring, were studied. All affected dogs appeared clinically inconspicuous, while sonography revealed the presence of renal cysts. The PKD-affected index… read more here.
Keywords: nonsense variant; lagotto romagnolo; pkd1; polycystic kidney ... See more keywords
Mutational Screening of PKD1 and PKD2 Genes in Iranian Population Diagnosed with Autosomal Dominant Polycystic Kidney Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2017.170209
Abstract: BACKGROUND Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the fourth most frequent cause of endstage renal disease (ESDR), occurring at a varying frequency of 1/400 to 1/800 persons. The disease affects all ethnic groups worldwide,… read more here.
Keywords: pkd1; disease; pkd2 genes; autosomal dominant ... See more keywords