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   Articles with "pkd1" as a keyword



Protein kinase D1 inhibition interferes with mitosis progression

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28651

Abstract: Protein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, very… read more here.

Keywords: mitosis progression; pkd1; mitosis; protein kinase ... See more keywords

Adipose-Specific Knockout of Protein Kinase D1 Suppresses de novo Lipogenesis in Mice via SREBP1c-dependent Signaling.

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recommendations! Published in 2021 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2021.112548

Abstract: Having healthy adipose tissue is essential for metabolic health, as excessive adipose tissue in the body can cause its dysregulation and driving chronic metabolic diseases. Protein kinase D1 (PKD1) is considered to be a key… read more here.

Keywords: pkd1; novo lipogenesis; lipogenesis; adipose tissue ... See more keywords

Pkd1-targeted mutation reveals a role for the Wolffian duct in autosomal dominant polycystic kidney disease

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recommendations! Published in 2019 at "Journal of Developmental Origins of Health and Disease"

DOI: 10.1017/s2040174419000436

Abstract: Abstract Several life-threatening diseases of the kidney have their origins in mutational events that occur during embryonic development. In this study, we investigate the role of the Wolffian duct (WD), the earliest embryonic epithelial progenitor… read more here.

Keywords: autosomal dominant; wolffian duct; pkd1; disease ... See more keywords

#1232 Integrating genotype and phenotype data is required for renal survival prediction in autosomal dominant polycystic kidney disease

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recommendations! Published in 2024 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfae069.267

Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the cause for 5-10% of end stage kidney disease (ESKD) worldwide. Accurate renal prognosis is essential for effective disease management. Investigation of the prognostic value of combining genetic… read more here.

Keywords: propkd score; kidney disease; pkd1; prediction ... See more keywords

Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory

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recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abd0033

Abstract: Social memory enables one to recognize and distinguish specific individuals. It is fundamental to social behaviors that can be mediated by the oxytocin receptor (OXTR), such as forming relationships. We investigated the molecular regulation and… read more here.

Keywords: social memory; pkd1; oxytocin receptor; phosphorylation ... See more keywords
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Autosomal dominant polycystic kidney disease in absence of renal cyst formation illustrates genetic interaction between WT1 and PKD1

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recommendations! Published in 2020 at "Journal of Medical Genetics"

DOI: 10.1136/jmedgenet-2019-106633

Abstract: Purpose Autosomal dominant polycystic kidney disease (ADPKD), caused by pathogenic variants of either PKD1 or PKD2, is characterised by wide interfamilial and intrafamilial phenotypic variability. This study aimed to determine the molecular basis of marked… read more here.

Keywords: pkd1; disease; wt1; autosomal dominant ... See more keywords

Lack of Pkd1 enhances intestinal integrity and motility prior to accelerated kidney cyst growth

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.1398

Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, primarily caused by PKD1 germline mutations. Polycystin-1, PKD1’s encoded protein, is essential to maintain kidney epithelial cell integrity, but its role in… read more here.

Keywords: mice; cyst; physiology; integrity ... See more keywords

Mutation Analysis of PKD1 and PKD2 Genes in a Large Italian Cohort Reveals Novel Pathogenic Variants Including A Novel Complex Rearrangement.

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recommendations! Published in 2023 at "Nephron"

DOI: 10.1159/000530657

Abstract: BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease of the kidney. It occurs in adulthood but is also rarely diagnosed in early childhood. The majority of the disease-causing variants observed… read more here.

Keywords: disease; pkd1 pkd2; mutation analysis; pkd1 ... See more keywords

Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis

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recommendations! Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0226145

Abstract: Toll-like receptor (TLR) signaling can contribute to the pathogenesis of arthritis. Disruption of TLR signaling at early stages of arthritis might thereby provide an opportunity to halt the disease progression and ameliorate outcomes. We previously… read more here.

Keywords: induced arthritis; pkd1; ameliorating effects; tlr ... See more keywords
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PKD and scaffold NHERF1 mediate hypoxia-induced gene expression in 3T3-L1 adipocytes.

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recommendations! Published in 2025 at "Journal of molecular endocrinology"

DOI: 10.1530/jme-25-0011

Abstract: Hypoxia has been implicated as a causal factor in mediating adipocyte dysfunction in obesity. Moreover, protein kinase D 1 (PKD1), a serine/threonine protein kinase, has been shown to contribute to diet-induced adiposity. Therefore, we investigated… read more here.

Keywords: gene expression; pkd1; hypoxia induced; hypoxia ... See more keywords

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease

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recommendations! Published in 2024 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2024.1356703

Abstract: Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson’s disease (PD). Thus, identifying the key signaling mechanisms regulating mitochondrial biogenesis is crucial to developing new treatment strategies for PD. We… read more here.

Keywords: mito met; culture; pkd1; mitopark ... See more keywords