The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.
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DOI: 10.1016/j.kint.2021.01.028
Abstract: Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2 mutations, causes progressive kidney cyst development and kidney failure. There is significant intrafamilial variability likely due to the genetic background and environmental/lifestyle factors;… read more here.
Keywords: kidney; genetic background; disease; pkd1rc ... See more keywords