PKG II effectively reversed EGF‐induced protein expression alterations in human gastric cancer cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10912
Abstract: Epidermal growth factor receptor (EGFR) plays an important role in gastric cancer (GC) progression. Our previous data demonstrated that type II cGMP‐dependent protein kinase (PKG II) could block the EGF‐EGFR axis as well as down‐stream… read more here.
Keywords: protein expression; gastric cancer; effectively reversed; pkg ... See more keywords
Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.126
Abstract: Our previous study demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF) induced tyrosine phosphorylation/activation of the EGF receptor (EGFR). This paper was designed to investigate the mechanism of the… read more here.
Keywords: egfr; kinase; type cgmp; pkg ... See more keywords
Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.05.008
Abstract: cGMP is a second messenger widely used in the nervous system and other tissues. One of the major effectors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase (PKG), which catalyzes the phosphorylation of… read more here.
Keywords: cgmp pkg; pkg signaling; signaling pathway; pkg ... See more keywords
Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105171
Abstract: Gastrodin, which is extracted from the Chinese herbal medicine Gastrodia elata Blume, can ameliorate neurogenesis after cerebral ischemia. However, it's possible underlying mechanisms remain still elusive. PDE9-cGMP-PKG signaling pathway is involved in the proliferation of… read more here.
Keywords: cgmp pkg; pde9 cgmp; cerebral ischemia; gastrodin ... See more keywords
C-type natriuretic peptide regulates sperm capacitation by the cGMP/PKG signalling pathway via Ca2+ influx and tyrosine phosphorylation.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2018.11.025
Abstract: RESEARCH QUESTION What is the effect of C-type natriuretic peptide (CNP) on human sperm capacitation in vitro and what is the mechanism of this effect? DESIGN CNP/NPR-B expression in the female rat genital tract was… read more here.
Keywords: sperm capacitation; cnp; cgmp; pkg ... See more keywords
Structural Basis of Analog Specificity in PKG I and II.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00369
Abstract: Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP-dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due… read more here.
Keywords: structural basis; isotype specificity; pkg; specificity ... See more keywords
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905558116
Abstract: Significance Despite being one of the first protein kinases discovered, cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase (PKG) has not been successfully crystallized previously, leaving many unanswered questions about its mechanism of activation. We report herein the… read more here.
Keywords: protein; mechanism; kinase; pkg ... See more keywords
Cost-effectiveness analysis of the Parkinson’s KinetiGraph and clinical assessment in the management of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Economics"
DOI: 10.1080/13696998.2022.2080437
Abstract: Abstract Aims The Parkinson’s KinetiGraph (PKG) is a wrist-worn movement recording system that collates continuous, objective, data during daily activities in people with Parkinson’s disease (PD) providing a report for clinicians. This study explores the… read more here.
Keywords: movement; assessment; pkg; disease ... See more keywords
Abstract 281: Phosphodiesterase 8/9 inhibition to sensitize squamous non-small cell lung cancer (NSCLC) to pemetrexed (PMX): A double-edge strategy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-281
Abstract: Introduction. Phosphosidesterases (PDE) are key regulators of cyclic nucleotide (cAMP/cGMP) signaling regulating many cellular processes including cell proliferation, growth arrest and apoptosis. In squamous NSCLC (SCC), PDE inhibitors (PDEi) have shown anti-tumor activity both as… read more here.
Keywords: cell; scc; pkg; pka ... See more keywords
Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000471938
Abstract: Background/Aims: Vascular relaxation caused by Triiodothyronine (T3) involves direct activation of endothelial cells (EC) and vascular smooth muscle cells (VSMC). Activation of protein kinase G (PKG) has risen as a novel contributor to the vasorelaxation… read more here.
Keywords: vasp signaling; vasorelaxation; vascular smooth; pkg ... See more keywords
Abstract 232: PDE5A Inhibition in Burn-induced Cardiac Dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.232
Abstract: Severe burn injury initiates a feedback cycle of inflammation, fibrosis and oxidative stress and others that may contribute to heart dysfunction via the PDE5A-cGMP-PKG pathway. Sildenafil (SIL) has been shown decrease immune adverse events in… read more here.
Keywords: pde5a; burn; heart; dysfunction ... See more keywords