Abstract 2418: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2418
Abstract: Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2… read more here.
Keywords: aerobic glycolysis; pkm2; carm1; cancer ... See more keywords