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   Articles with "pknb" as a keyword



A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700385

Abstract: The Mycobacterium tuberculosis Ser/Thr kinase PknB is implicated in the regulation of bacterial cell growth and cell division. The intracellular kinase function of PknB is thought to be triggered by peptidoglycan (PGN) fragments that are… read more here.

Keywords: kinase; spectroscopy; pknb; pgn ... See more keywords
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Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

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recommendations! Published in 2018 at "Cell Reports"

DOI: 10.1016/j.celrep.2018.09.004

Abstract: Summary Tuberculosis claims >1 million lives annually, and its causative agent Mycobacterium tuberculosis is a highly successful pathogen. Protein kinase B (PknB) is reported to be critical for mycobacterial growth. Here, we demonstrate that PknB-depleted… read more here.

Keywords: cwlm essential; tuberculosis; pknb; pknb substrate ... See more keywords
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In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with β-Lactams To Inhibit Mycobacterial Growth.

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recommendations! Published in 2018 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.8b00905

Abstract: New tools and concepts are needed to combat antimicrobial resistance. Actinomycetes and firmicutes share several eukaryotic-like Ser/Thr kinases (eSTK) that offer antibiotic development opportunities, including PknB, an essential mycobacterial eSTK. Despite successful development of potent… read more here.

Keywords: kinase inhibitors; screen structural; silico screen; pknb ... See more keywords
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A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-04108-7

Abstract: Protein kinase B (PknB) is one of the Mycobacterium tuberculosis serine/threonine protein kinases and has an essential role in sustaining mycobacterial growth. Here, we identified and characterized a novel small molecule compound named IMB-YH-8 that… read more here.

Keywords: inhibitor; imb; tuberculosis; protein kinase ... See more keywords